细胞状态对异染色质动态的影响

IF 4.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Journal Pub Date : 2024-11-06 DOI:10.1042/bcj20240139

Abby Trouth,Giovana M B Veronezi,Srinivas Ramachandran

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引用次数: 0

摘要

当细胞处于发育、活动和疾病的不同阶段时，建立、维持和去除与异染色质相关的组蛋白翻译后修饰对于塑造基因组结构和功能至关重要。抑制性染色质景观的动态调控已在几种关键细胞状态（生殖细胞、活化的免疫细胞、活跃的复制细胞和静止细胞）中得到证实，其基本机制存在显著差异。在这里，我们将讨论这些不同背景下的细胞状态在引导和维持所观察到的染色质景观中的作用。这些研究揭示了异染色质结构对细胞存在的功能环境的高度响应，反过来，它们对细胞的稳定特性也有贡献。

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The impact of cell states on heterochromatin dynamics.

Establishing, maintaining, and removing histone post-translational modifications associated with heterochromatin is critical for shaping genomic structure and function as a cell navigates different stages of development, activity, and disease. Dynamic regulation of the repressive chromatin landscape has been documented in several key cell states - germline cells, activated immune cells, actively replicating, and quiescent cells - with notable variations in underlying mechanisms. Here, we discuss the role of cell states of these diverse contexts in directing and maintaining observed chromatin landscapes. These investigations reveal heterochromatin architectures that are highly responsive to the functional context of a cell's existence and, in turn, their contribution to the cell's stable identity.

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来源期刊

Biochemical Journal 生物-生化与分子生物学

CiteScore

8.00

自引率

0.00%

发文量

255

审稿时长

1 months

期刊介绍： Exploring the molecular mechanisms that underpin key biological processes, the Biochemical Journal is a leading bioscience journal publishing high-impact scientific research papers and reviews on the latest advances and new mechanistic concepts in the fields of biochemistry, cellular biosciences and molecular biology. The Journal and its Editorial Board are committed to publishing work that provides a significant advance to current understanding or mechanistic insights; studies that go beyond observational work using in vitro and/or in vivo approaches are welcomed. Painless publishing: All papers undergo a rigorous peer review process; however, the Editorial Board is committed to ensuring that, if revisions are recommended, extra experiments not necessary to the paper will not be asked for. Areas covered in the journal include: Cell biology Chemical biology Energy processes Gene expression and regulation Mechanisms of disease Metabolism Molecular structure and function Plant biology Signalling