胰岛素样生长因子系统与衰老

IF 22 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Cheryl A Conover,Claus Oxvig
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引用次数: 0

摘要

有确凿证据表明,胰岛素样生长因子(IGF)信号传导与衰老过程的基本方面有关。然而,IGF 系统的细胞外部分非常复杂,包括各种受体、配体效应器、高亲和力 IGF 结合蛋白、蛋白酶和内源性抑制剂,所有这些因素及其生物学背景都必须考虑在内。IGF 系统的组成成分在进化上是保守的,这凸显了了解该系统在生理学和病理生理学中的重要性。本综述将简要介绍 IGF 系统的不同组成部分,然后讨论有关 IGF 与衰老的过去和当前文献,重点是细胞衰老、衰老模式生物、百岁老人遗传学以及三种与年龄有关的疾病--肺纤维化、阿尔茨海默病和黄斑变性--在适当的鼠类模型和人类中的表现。机理上的共性表明,IGF 系统成分可能是疾病的驱动因素,也可能是促进人类健康衰老的潜在靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Insulin-like Growth Factor System and Aging.
There is strong evidence that insulin-like growth factor (IGF) signaling is involved in fundamental aspects of the aging process. However, the extracellular part of the IGF system is complex with various receptors, ligand effectors, high affinity IGF binding proteins, proteinases and endogenous inhibitors that all, along with their biological context, must be considered. The IGF system components are evolutionarily conserved, underscoring the importance of understanding this system in physiology and pathophysiology. This review will briefly describe the different components of the IGF system and then discuss past and current literature regarding the IGFs and aging, with a focus on cellular senescence, model organisms of aging, centenarian genetics, and three age-related diseases - pulmonary fibrosis, Alzheimer's disease, and macular degeneration - in appropriate murine models and in humans. Commonalities in mechanism suggest conditions where IGF system components may be disease drivers and potential targets in promoting healthy aging in humans.
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来源期刊
Endocrine reviews
Endocrine reviews 医学-内分泌学与代谢
CiteScore
42.00
自引率
1.00%
发文量
29
期刊介绍: Endocrine Reviews, published bimonthly, features concise timely reviews updating key mechanistic and clinical concepts, alongside comprehensive, authoritative articles covering both experimental and clinical endocrinology themes. The journal considers topics informing clinical practice based on emerging and established evidence from clinical research. It also reviews advances in endocrine science stemming from studies in cell biology, immunology, pharmacology, genetics, molecular biology, neuroscience, reproductive medicine, and pediatric endocrinology.
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