从超耐药精神分裂症患者中生成诱导多能干细胞系 UJSi004-A

IF 0.8 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Stem cell research Pub Date : 2024-10-09 DOI:10.1016/j.scr.2024.103575

Siyu Xi , Bing Xue , Yupeng Wang , Zhenghua Shan , Tianchi Song , Jing Sun , Shengying Qin

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引用次数: 0

摘要

精神分裂症是一种严重的精神疾病，具有致残性。诱导多能干细胞（iPSC）是通过对超耐药精神分裂症（UTRS）患者的外周血单核细胞（PBMC）进行重编程而产生的。这种 iPSC 细胞系携带患者的遗传信息，是研究疾病机理和开发新疗法的良好模型。

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Generation of patient-derived induced pluripotent stem cell line UJSi004-A from ultra-treatment-resistant schizophrenia

Schizophrenia is a severe mental illness with disabling effects. Induced pluripotent stem cells (iPSCs) are generated by reprogramming peripheral blood mononuclear cells (PBMCs) from patients with ultra-treatment-resistant schizophrenia (UTRS). iPSCs have normal karyotype, express pluripotency markers and differentiate into three germ layers in vivo. This iPSC cell line carries the genetic information of the patient and is a good model for studying disease mechanisms and developing new therapies.

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来源期刊

Stem cell research 生物-生物工程与应用微生物

CiteScore

2.20

自引率

8.30%

发文量

338

审稿时长

55 days

期刊介绍： Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancer stem cells, developmental studies, stem cell genomes, and translational research. Stem Cell Research publishes 6 issues a year.