在脑-血管-免疫界面上进行开拓性发现和治疗

IF 45.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2024-10-17 DOI:10.1016/j.cell.2024.09.018

Katerina Akassoglou, Dimitrios Davalos, Andrew S. Mendiola, Mark A. Petersen, Jae Kyu Ryu, Christian Schachtrup, Zhaoqi Yan

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引用次数: 0

摘要

大脑-血管-免疫界面已成为大脑生理和疾病的动态参与者。我们建议将血管风险因素与遗传易感性结合起来，作为发现神经炎症、神经变性和神经修复等多基因神经疾病的机制和疗法的纽带。

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Pioneering discovery and therapeutics at the brain-vascular-immune interface

The brain-vascular-immune interface has emerged as a dynamic player in brain physiology and disease. We propose integrating vascular risk factors with genetic susceptibility as the nexus for the discovery of mechanisms and therapies for neuroinflammation, neurodegeneration, and neurorepair across polygenic neurologic diseases.

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.