The choice of resuscitation fluids—Ionic composition matters. Author’s reply

We would like to thank Mertzlufft for raising the issue of importance of the physiological composition of crystalloid fluids [1]. In the process of guideline generation, we selected questions with sufficient clinical evidence to support a recommendation [2]. In that regard, we have addressed the question of the balanced crystalloids versus saline, for which multiple randomized clinical trials have been conducted. As highlighted in the guideline document and the article by Mertzlufft et al., there is limited clinical evidence to support other questions about the composition of different balanced crystalloids [3]. This point has been highlighted in the guidelines as an area for further research [2].