APOE 𝜀4相关血脑屏障破坏与微结构异常有关

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2024-10-16 DOI:10.1002/alz.14302

Emilie T. Reas, Seraphina K. Solders, Amaryllis Tsiknia, Curtis Triebswetter, Qian Shen, Charlotte S. Rivera, Murray J. Andrews, Austin Alderson-Myers, James B. Brewer

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引用次数: 0

摘要

阿尔茨海默病（AD）会出现血脑屏障（BBB）功能障碍。然而，血脑屏障功能障碍出现在阿尔茨海默病的哪个阶段，以及它是否会导致神经变性，目前仍不清楚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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APOE 𝜀4-related blood–brain barrier breakdown is associated with microstructural abnormalities

Blood–brain barrier (BBB) dysfunction occurs in Alzheimer's disease (AD). Yet, the stage at which it appears along the AD time course and whether it contributes to neurodegeneration remain unclear.

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.