T 细胞中的废物管理和细胞死亡

IF 17.3 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2024-10-16 DOI:10.1038/s41556-024-01538-0

Douglas R. Green

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引用次数: 0

摘要

T 淋巴细胞被激活后，必须消耗燃料作为能量和生物材料，以维持快速增殖和分化。因此，产生的废物必须加以管理。现在，一项新研究探讨了活化的 CD8+ 效应 T 细胞如何处理氨，以及这对这些细胞的存活和功能有何影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Waste management and cell death in T cells

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Waste management and cell death in T cells

After being activated, T lymphocytes must consume fuel for energy and biomaterials to sustain rapid proliferation and differentiation. As a consequence, waste is generated that must be managed. A new study now explores how activated CD8+ effector T cells handle ammonia, and how this impacts the survival and function of these cells.

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology