Keishinieppiittokajutsubu 对低气压引起的关节炎模型大鼠疼痛反应的镇痛效果

IF 3 3区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of pharmacological sciences Pub Date : 2024-10-09 DOI:10.1016/j.jphs.2024.10.002

Yuki Kurauchi , Kana Inoue , Tomoka Kawakami , Manami Ueda , Tomoko Yamaguchi , Junji Akaki , Masahiko Komorisono , Hiroshi Katsuki

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引用次数: 0

摘要

类风湿性关节炎（RA）是一种引起关节炎症的疾病，会导致疼痛和肿胀。气压降低会诱发类风湿关节炎的疼痛症状，但目前还没有合适的动物模型和药理评估。Keishinieppiittokajutsubu（KNEIJB）是一种用于治疗 RA 的康波药物，但其作用机制尚不清楚。在这里，我们发现 KNEIJB 可抑制低气压（LP）诱导的 CFA 关节炎模型大鼠的疼痛反应。此外，我们还发现 KNEIJB 降低了血浆 IL-6 的水平。这些结果表明，KNEIJB可能有益于治疗由低气压诱发的RA或其他关节痛。

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Analgesic effect of Keishinieppiittokajutsubu on low barometric pressure-induced pain response in arthritic model rats

Rheumatoid arthritis (RA) is a disease that causes inflammation of joints, resulting in pain and swelling. Reduced barometric pressure induces painful symptom of RA, but there is no appropriate animal model and pharmacological evaluation. Keishinieppiittokajutsubu (KNEIJB), a Kampo medicine used to treat RA; however, its mechanism of action is not clear. Here, we found that KNEIJB suppressed the low barometric pressure (LP)-induced pain response in CFA-induced arthritic model rats. Furthermore, we found that KNEIJB reduced plasma IL-6 levels. These results suggest that KNEIJB might be beneficial in the treatment of RA or some other arthralgia induced by LP.

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来源期刊

Journal of pharmacological sciences 医学-药学

CiteScore

6.20

自引率

2.90%

发文量

104

审稿时长

31 days

期刊介绍： Journal of Pharmacological Sciences (JPS) is an international open access journal intended for the advancement of pharmacological sciences in the world. The Journal welcomes submissions in all fields of experimental and clinical pharmacology, including neuroscience, and biochemical, cellular, and molecular pharmacology for publication as Reviews, Full Papers or Short Communications. Short Communications are short research article intended to provide novel and exciting pharmacological findings. Manuscripts concerning descriptive case reports, pharmacokinetic and pharmacodynamic studies without pharmacological mechanism and dose-response determinations are not acceptable and will be rejected without peer review. The ethnopharmacological studies are also out of the scope of this journal. Furthermore, JPS does not publish work on the actions of biological extracts unknown chemical composition.