肠道微生物群干预对接受放疗的肝细胞癌患者炎症反应和细胞免疫功能的影响

IF 1.7 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences Pub Date : 2024-10-14 DOI:10.1016/j.jrras.2024.101131

Liying Liu , Yanna Fan , Hongying Pi

{"title":"肠道微生物群干预对接受放疗的肝细胞癌患者炎症反应和细胞免疫功能的影响","authors":"Liying Liu , Yanna Fan , Hongying Pi","doi":"10.1016/j.jrras.2024.101131","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the changes in nutritional status, inflammatory response and cellular immune status of Hepatocellular Carcinoma (HCC) patients who received radiotherapy under GMB intervention and to clarify the effect of GMB intervention on HCC.</div></div><div><h3>Methods</h3><div>Ninety-two patients with HCC receiving radiotherapy were randomized into study and observation groups, 46 in each group. The control group used conventional radiotherapy, and the study group used the gut microbiota intervention. The gut microbiota before and after radiotherapy, and the liver function, clinical efficacy, inflammatory response, cellular immunity, and nutritional status before and after treatment were compared.</div></div><div><h3>Results</h3><div>Compared with the control group, the number of lactobacillus and Bifidobacterium increased significantly, the clinical efficacy was significantly enhanced, the liver function, cellular immunity and nutritional status were significantly improved, and the inflammatory response was significantly reduced, with statistically significant differences (P < 0.05).</div></div><div><h3>Conclusion</h3><div>gut microbiota intervention can improve the effect of radiotherapy and improve liver function in patients, and the mechanism is related to regulating cellular immune function of patients and inhibiting inflammatory response in patients.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"17 4","pages":"Article 101131"},"PeriodicalIF":1.7000,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of gut microbiota intervention on inflammatory responses and cellular immune function in hepatocellular carcinoma patients undergoing radiotherapy\",\"authors\":\"Liying Liu , Yanna Fan , Hongying Pi\",\"doi\":\"10.1016/j.jrras.2024.101131\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>To analyze the changes in nutritional status, inflammatory response and cellular immune status of Hepatocellular Carcinoma (HCC) patients who received radiotherapy under GMB intervention and to clarify the effect of GMB intervention on HCC.</div></div><div><h3>Methods</h3><div>Ninety-two patients with HCC receiving radiotherapy were randomized into study and observation groups, 46 in each group. The control group used conventional radiotherapy, and the study group used the gut microbiota intervention. The gut microbiota before and after radiotherapy, and the liver function, clinical efficacy, inflammatory response, cellular immunity, and nutritional status before and after treatment were compared.</div></div><div><h3>Results</h3><div>Compared with the control group, the number of lactobacillus and Bifidobacterium increased significantly, the clinical efficacy was significantly enhanced, the liver function, cellular immunity and nutritional status were significantly improved, and the inflammatory response was significantly reduced, with statistically significant differences (P < 0.05).</div></div><div><h3>Conclusion</h3><div>gut microbiota intervention can improve the effect of radiotherapy and improve liver function in patients, and the mechanism is related to regulating cellular immune function of patients and inhibiting inflammatory response in patients.</div></div>\",\"PeriodicalId\":16920,\"journal\":{\"name\":\"Journal of Radiation Research and Applied Sciences\",\"volume\":\"17 4\",\"pages\":\"Article 101131\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-10-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Radiation Research and Applied Sciences\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1687850724003157\",\"RegionNum\":4,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Radiation Research and Applied Sciences","FirstCategoryId":"103","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1687850724003157","RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

方法将92例接受放疗的肝细胞癌（HCC）患者随机分为研究组和观察组，每组46例。对照组采用常规放疗，研究组采用肠道微生物群干预。结果与对照组相比，研究组乳酸杆菌和双歧杆菌数量明显增加，临床疗效明显提高，肝功能、细胞免疫和营养状况明显改善，炎症反应明显减轻，差异有统计学意义（P < 0.05）。结论肠道微生物群干预可提高放疗效果，改善患者肝功能，其机制与调节患者细胞免疫功能、抑制患者炎症反应有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Effect of gut microbiota intervention on inflammatory responses and cellular immune function in hepatocellular carcinoma patients undergoing radiotherapy

Objective

To analyze the changes in nutritional status, inflammatory response and cellular immune status of Hepatocellular Carcinoma (HCC) patients who received radiotherapy under GMB intervention and to clarify the effect of GMB intervention on HCC.

Methods

Ninety-two patients with HCC receiving radiotherapy were randomized into study and observation groups, 46 in each group. The control group used conventional radiotherapy, and the study group used the gut microbiota intervention. The gut microbiota before and after radiotherapy, and the liver function, clinical efficacy, inflammatory response, cellular immunity, and nutritional status before and after treatment were compared.

Results

Compared with the control group, the number of lactobacillus and Bifidobacterium increased significantly, the clinical efficacy was significantly enhanced, the liver function, cellular immunity and nutritional status were significantly improved, and the inflammatory response was significantly reduced, with statistically significant differences (P < 0.05).

Conclusion

gut microbiota intervention can improve the effect of radiotherapy and improve liver function in patients, and the mechanism is related to regulating cellular immune function of patients and inhibiting inflammatory response in patients.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Radiation Research and Applied Sciences MULTIDISCIPLINARY SCIENCES-

自引率

5.90%

发文量

130

审稿时长

16 weeks

期刊介绍： Journal of Radiation Research and Applied Sciences provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and applications of nuclear, radiation and isotopes in biology, medicine, drugs, biochemistry, microbiology, agriculture, entomology, food technology, chemistry, physics, solid states, engineering, environmental and applied sciences.