生活必需品 8 和美国乳腺癌妇女的心血管疾病发病率

IF 12 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Jacc: Cardiooncology Pub Date : 2024-10-01 DOI:10.1016/j.jaccao.2024.07.008

Elena Wadden MD , Alexi Vasbinder PhD, RN , Vidhushei Yogeswaran MD , Aladdin H. Shadyab PhD , Nazmus Saquib MBBS, MPH, PhD , Yangbo Sun PhD , Lisa Warsinger Martin MD , Ramesh Mazhari MD , JoAnn E. Manson MD, DrPH , Marcia Stefanick PhD , Ana Barac MD, PhD , Michael S. Simon MD , Kerryn Reding PhD, MPH, RN , Richard K. Cheng MD, MS

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引用次数: 0

摘要

背景对乳腺癌（BC）女性患者的生活方式风险因素与心血管疾病（CVD）风险之间的关系探索不足。主要暴露是在 BC 诊断前评估的 LE8 分数。LE8 分值被分为低（0-59 分）、中（60-79 分）和高（80-100 分）心血管健康（CVH）等级。主要终点是心血管疾病事件的综合指数，其中包括冠心病（定义为心肌梗死和冠状动脉血运重建）、心血管疾病死亡和中风。我们计算了心血管疾病的累积发病率，并估算了危险比。结果在 7,165 名参与者中，确诊 BC 时的中位年龄为 70.1 岁。LE8 评分的平均值为 62.0 ± 12.2。中位随访期为 6 年，共发生 490 起心血管疾病综合事件。与中度和高度CVH相比，低CVH发生心血管事件的风险最高。与低 CVH 相比，中度 CVH 发生心血管事件的危险比为 0.57（95% CI：0.46-0.69），高度 CVH 为 0.34（95% CI：0.20-0.59）。结论美国 BC 女性患者中，LE8 评分越高，发生心血管疾病的风险越低。

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Life’s Essential 8 and Incident Cardiovascular Disease in U.S. Women With Breast Cancer

Background

Relationships between lifestyle risk factors and cardiovascular disease (CVD) risk in women with breast cancer (BC) are underexplored.

Objectives

To evaluate the incidence of CVD in relation to the Life’s Essential 8 (LE8) score among women with BC.

Methods

Data from the Women’s Health Initiative were utilized. The primary exposure was the LE8 score assessed prior to BC diagnosis. The LE8 score was stratified into low (0-59), moderate (60-79), and high (80-100) cardiovascular health (CVH). The primary endpoint was a composite of incident CVD events, which included coronary heart disease, defined as myocardial infarction along with coronary revascularization, CVD death, and stroke. We calculated the cumulative incidence of CVD and estimated hazard ratios.

Results

Among 7,165 participants, the median age was 70.1 years at BC diagnosis. The mean LE8 score was 62.0 ± 12.2. Over a median follow-up period of 6 years, 490 composite CVD events occurred. The risk of CVD events was highest for low CVH compared with moderate and high CVH. Compared with low CVH, the hazard ratio for incident CVD was 0.57 (95% CI: 0.46-0.69) for moderate CVH and 0.34 (95% CI: 0.20-0.59) for high CVH. LE8, in conjunction with age, provided a C-statistic of 0.74 for the composite risk of CVD.

Conclusions

Higher LE8 scores were associated with a lower risk of incident CVD among women with BC in the United States.

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来源期刊

Jacc: Cardiooncology Multiple-

CiteScore

12.50

自引率

6.30%

发文量

106

期刊介绍： JACC: CardioOncology is a specialized journal that belongs to the esteemed Journal of the American College of Cardiology (JACC) family. Its purpose is to enhance cardiovascular care for cancer patients by publishing high-quality, innovative scientific research and sharing evidence-based knowledge. The journal aims to revolutionize the field of cardio-oncology and actively involve and educate professionals in both cardiovascular and oncology fields. It covers a wide range of topics including pre-clinical, translational, and clinical research, as well as best practices in cardio-oncology. Key areas of focus include understanding disease mechanisms, utilizing in vitro and in vivo models, exploring novel and traditional therapeutics (across Phase I-IV trials), studying epidemiology, employing precision medicine, and investigating primary and secondary prevention. Amyloidosis, cardiovascular risk factors, heart failure, and vascular disease are some examples of the disease states that are of particular interest to the journal. However, it welcomes research on other relevant conditions as well.