移行体：生物生成、生理作用和治疗潜力。

IF 7.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2024-10-14 DOI:10.1083/jcb.202403051

Haifeng Jiao,Li Yu

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引用次数: 0

摘要

迁移体（Migrasomes）是在迁移细胞中发现的囊泡结构，它产生于牵引纤维的连接处或顶端，并逐渐成长为微型囊泡。移行体因其在细胞间通信中的作用和潜在的治疗意义而备受关注。本综述概述了移行体生物学的最新进展，涵盖了移行体的生物生成机制、基本生理作用、与各种疾病的关联以及潜在的治疗应用。此外，我们还分享了我们对移行体研究未来潜在方向的看法，并强调了这一不断发展的研究领域所面临的挑战。

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Migrasomes: Biogenesis, physiological roles, and therapeutic potentials.

Migrasomes, vesicular structures discovered in migrating cells, arise from the junctions or tips of retraction fibers, and gradually grow to microscale vesicles. Migrasomes have garnered attention for their role in intercellular communication and potential therapeutic implications. This review presents an overview of recent advances in migrasome biology, covering the mechanisms of migrasome biogenesis, essential physiological roles, and their association with various diseases, alongside potential therapeutic applications. Furthermore, we share our perspectives on potential future directions in the study of migrasomes and highlight the challenges that remain in this developing area of research.

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.