在咪唑的帮助下以炔酮为原料一步合成 1,3-二酮

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2024-10-14 DOI:10.1134/S1070428024070091

Xianrong Cai, Jie Xiang, Jia Zheng, Juan Tang, Jian Su, Chunru Cheng

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引用次数: 0

摘要

我们利用迈克尔加成-亲核取代反应过程，从炔酮类化合物开始，高效地一步合成了 1,3-二酮。该反应首先是咪唑与炔酮发生迈克尔加成反应，然后用水进行亲核取代。通过核磁共振光谱对最终产物 1,3-二酮进行了表征。该研究表明，此类反应可在温和的条件下一锅成功完成，1,3-二酮的收率高达 65% 至 93%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

One-Pot Synthesis of 1,3-Diketones from Alkynones with the Assistance of Imidazole

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One-Pot Synthesis of 1,3-Diketones from Alkynones with the Assistance of Imidazole

An efficient one-pot synthesis of 1,3-diketones has been synthesized starting from alkynones using a Michael addition–nucleophilic substitution reaction process. The reaction starts with the Michael addition of imidazoles to alkynones, followed by the nucleophilic substitution by water. The final product 1,3-diketones were characterized by the NMR spectra. This study demonstrated that such reactions could successfully occur in one pot under mild conditions with a high yield of 1,3-diketones from 65 to 93%.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.