卵巢癌化疗后出现弥漫性皮肤鳞状细胞原位癌，使用PD1抑制剂后病情缓解

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports Pub Date : 2024-10-11 DOI:10.1016/j.gore.2024.101528

Jess Durbin , Taylor A. Rives , Dava Piecoro , Charles S. Dietrich

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引用次数: 0

摘要

患者是一名74岁的女性，最初出现恶性胸腔积液，评估结果显示程序性细胞死亡配体1（PDL1）阳性，为IV期高级别浆液性卵巢癌。在开始使用标准化疗药物卡铂和紫杉醇后，患者的腹部、背部和双侧上下肢出现了弥漫性瘙痒皮疹。皮疹活检显示为弥漫性不可切除的皮肤鳞状细胞原位癌（cSCC）。因此，在她的新辅助化疗方案中加入了 PD1 抑制剂，结果在手术时，转移性卵巢癌和弥漫性原位皮肤鳞状细胞癌都出现了完全反应。

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Development of diffuse cutaneous squamous cell carcinoma in situ after chemotherapy for ovarian carcinoma and remission with PD1-inhibitor

This is a 74-year-old female, initially presenting with malignant pleural effusion, and evaluation revealed programmed cell death ligand 1 (PDL1)-positive stage IV high grade serous ovarian cancer. Following initiation of standard chemotherapy agents, carboplatin and paclitaxel, the patient developed a diffuse, itchy rash over her abdomen, back, and bilateral upper and lower extremities. Biopsy of the rash revealed a diffuse non-resectable cutaneous squamous cell skin carcinoma (cSCC) in situ. Consequently, a PD1-inhibitor was added to her neoadjuvant chemotherapy regimen, which resulted in complete response to both metastatic ovarian and diffuse cSCC in situ at time of surgery.

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来源期刊

Gynecologic Oncology Reports OBSTETRICS & GYNECOLOGY-

CiteScore

2.00

自引率

0.00%

发文量

183

审稿时长

41 days

期刊介绍： Gynecologic Oncology Reports is an online-only, open access journal devoted to the rapid publication of narrative review articles, survey articles, case reports, case series, letters to the editor regarding previously published manuscripts and other short communications in the field of gynecologic oncology. The journal will consider papers that concern tumors of the female reproductive tract, with originality, quality, and clarity the chief criteria of acceptance.