可见光介导的环状 N-磺酰基酮亚胺的脱羧二氟烷基化反应：二氟烷基化 Cα-tetrasubstituted α-amino acid 衍生物的高效合成

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2024-10-05 DOI:10.1016/j.tet.2024.134294

Guo-Zhen Wei, Xiao-Han Qiu, Lei Guo, Ming Bian, Hui-Yu Chen, Yu-Ning Gao, Zhen-Jiang Liu

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引用次数: 0

摘要

通过可见光介导的光氧化催化过程，开发出了一种环状 N-磺酰基酮亚胺与二氟烷基羧酸酯的高效脱羧二氟烷基化方法。该方法为在温和简单的条件下合成二氟烷基化 Cα-tetrasubstituted α-amino acid 衍生物提供了一条直接的途径，而且产率适中，官能团耐受性极佳。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Visible light mediated decarboxylative difluoroalkylations of cyclic N-sulfonyl ketimines: Efficient synthesis of difluoroalkylated Cα-tetrasubstituted α-amino acid derivatives

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Visible light mediated decarboxylative difluoroalkylations of cyclic N-sulfonyl ketimines: Efficient synthesis of difluoroalkylated Cα-tetrasubstituted α-amino acid derivatives

An efficient decarboxylative difluoroalkylation method of cyclic N-sulfonyl ketimines with difluoroalkyl carboxylates has been developed through visible light-mediated photoredox catalysis process. This protocol provides a straightforward route for the synthesis of difluoroalkylated C^α-tetrasubstituted α-amino acid derivatives in moderate to good yields with excellent functional group tolerance under mild and simple conditions.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.