高保真丙醛功能化聚乙二醇：合成与应用

IF 5.8 2区化学 Q1 POLYMER SCIENCE

European Polymer Journal Pub Date : 2024-10-03 DOI:10.1016/j.eurpolymj.2024.113489

Xiaoqing Chen , Guoxing Xu , Xuemei Zhang , Chao Geng , Mengli Wang , Yang Fu , Zhen Lv , Shuai Wang , Zimeng Guo , Shixue Wang

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引用次数: 0

摘要

通过置换和氧化过程合成高保真 PEGn-Alds 的经济、高效方法已经开发出来，为获得高纯度 PEGn-Alds 提供了一条新途径，尤其解决了 PEG 主链在氧化步骤中过氧化和断裂的问题。一系列具有不同官能团或拓扑结构的高保真 PEGn-Alds 的合成进一步证明了这种新方法的多功能性。此外，PEGn-Alds 还具有良好的生物相容性、修饰肽和自组装成胶束的潜在能力，这为合成高质量药物和开发新型疗法奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

High-fidelity propionaldehyde functionalized Poly(ethylene glycol): Synthesis and applications

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High-fidelity propionaldehyde functionalized Poly(ethylene glycol): Synthesis and applications

An economical and efficient approach for synthesizing high-fidelity PEG_n-Alds through a substitution and oxidation process has been developed, providing a new pathway for obtaining high-purity PEG_n-Alds, particularly addressing the issue of peroxidation and breakage of PEG main chains in the oxidation step. The synthesis of a series of high-fidelity PEG_n-Alds with different functional groups or topological structures further proves the versatility of this new method. Additionally, PEG_n-Alds also exhibit good biocompatibility, and potential ability to modify peptides and self-assembly to micelles, this lays a foundation for synthesizing high-quality drugs and developing novel therapeutics.

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来源期刊

European Polymer Journal 化学-高分子科学

CiteScore

9.90

自引率

10.00%

发文量

691

审稿时长

23 days

期刊介绍： European Polymer Journal is dedicated to publishing work on fundamental and applied polymer chemistry and macromolecular materials. The journal covers all aspects of polymer synthesis, including polymerization mechanisms and chemical functional transformations, with a focus on novel polymers and the relationships between molecular structure and polymer properties. In addition, we welcome submissions on bio-based or renewable polymers, stimuli-responsive systems and polymer bio-hybrids. European Polymer Journal also publishes research on the biomedical application of polymers, including drug delivery and regenerative medicine. The main scope is covered but not limited to the following core research areas: Polymer synthesis and functionalization • Novel synthetic routes for polymerization, functional modification, controlled/living polymerization and precision polymers. Stimuli-responsive polymers • Including shape memory and self-healing polymers. Supramolecular polymers and self-assembly • Molecular recognition and higher order polymer structures. Renewable and sustainable polymers • Bio-based, biodegradable and anti-microbial polymers and polymeric bio-nanocomposites. Polymers at interfaces and surfaces • Chemistry and engineering of surfaces with biological relevance, including patterning, antifouling polymers and polymers for membrane applications. Biomedical applications and nanomedicine • Polymers for regenerative medicine, drug delivery molecular release and gene therapy The scope of European Polymer Journal no longer includes Polymer Physics.