体育锻炼可改善维生素 D 对 2 型糖尿病诱导的大鼠肾毒性的血液学影响

IF 2.3 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2024-10-04 DOI:10.1016/j.bbrep.2024.101839

Halimat Amin Abdulrahim , Adeyemi Fatai Odetayo , Adeoye Tunwagun David , Yusuf Funsho Abdulquadri , Rofiat Oluwasheun Sheu , Pelumi Kikelomo Oluwafemi , Kazeem Bidemi Okesina , Luqman Aribidesi Olayaki

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引用次数: 0

摘要

导言在全球范围内，导致肾功能障碍的主要原因之一是糖尿病（DM），而糖尿病引起的肾毒性与贫血有关。目前，许多抗糖尿病药物已被设计用于治疗这种疾病，但这些药物也有其不良反应，如贫血和急性肾损伤。因此，我们探讨了在运动或不运动的情况下使用维生素 D 来治疗 DM 引起的肾功能障碍。方法将 36 只 Wistar 大鼠随机分为六组：对照组（药物治疗）、未治疗糖尿病组（HFD + STZ）、糖尿病 + 维生素 D 组（HFD + STZ + 维生素 D）、糖尿病 + 运动组（HFD + STZ + 运动）、糖尿病 + 维生素 D + 运动组（HFD + STZ + 维生素 D + 运动）、糖尿病 + 二甲双胍组（HFD + STZ + 二甲双胍）。结果无论是否运动，维生素 D 都能显著降低 T2DM 引起的高血糖。此外，由 T2DM 引起的尿素、肌酐、乳酸脱氢酶、乳酸、胆固醇和甘油三酯的增加也有所减少，而由 DM 引起的高密度脂蛋白的减少则有所上升。这些事件与红细胞、血细胞比容值、血红蛋白、促红细胞生成素的显著增加和白细胞计数的减少有关。此外，无论是否运动，维生素 D 都能逆转 T2DM 诱导的促氧化和促炎症标志物的增加。观察到的这种氧化-炎症反应与黄嘌呤氧化酶活性和尿酸浓度的显著增加有关。结论我们的研究结果表明，运动增强了维生素 D 对 HFD + STZ 诱导的 T2DM 动物的血液学效应。

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Physical exercise improved the hematological effect of vitamin D in type 2 diabetes mellitus-induced nephrotoxicity in rats

Introduction

Globally, one of the major causes of renal dysfunction is diabetes mellitus (DM), and diabetic-induced nephrotoxicity has been linked with anemia. Presently, numerous antidiabetic drugs have been designed for the management of this disorder but they possess their undesirable effects such as anemia and acute kidney injury. Hence, we explore the use of vitamin D with or without exercise for the management of DM-induced renal dysfunction.

Methods

Thirty-six (36) Wistar rats were randomly separated into six (6) groups: control (vehicle treated), diabetes untreated (HFD + STZ), diabetes + vitamin D (HFD + STZ + vitamin D), diabetes + exercise (HFD + STZ + exercise), diabetes + vitamin D + exercise (HFD + STZ + vitamin D+ exercise), diabetes + metformin (HFD + STZ + metformin).

Results

Vitamin D with or without exercise significantly reduced T2DM-induced hyperglycemia. Also, a decrease in T2DM-induced increase in urea, creatinine, lactate dehydrogenase, lactate, cholesterol, and triglyceride and a rise in DM-associated reduction in high-density lipoprotein. These events were associated with a significant increase in red blood cells, hematocrit value, hemoglobin, erythropoietin, and a decrease in white blood cell count. Furthermore, vitamin D with or without exercise reversed T2DM-induced increase in pro-oxidant and pro-inflammatory markers. This observed oxido-inflammatory response was associated with a significant increase in xanthine oxidase activities and uric acid concentration. Interestingly, better recovery rates from DM-associated hematological imbalance were discovered in rats co-treated with vitamin D and exercise.

Conclusion

Our findings revealed that exercise enhanced the hematological effect of vitamin D in HFD + STZ-induced T2DM animals.

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.