LIPOPROTEIN(A) AND CARDIOVASCULAR RISK. A RETROSPECTIVE COHORT STUDY FROM NYC/HHC+ PUBLIC HOSPITAL IN NEW YORK CITY

Therapeutic Area

ASCVD/CVD Risk Factors

Background

Lipoprotein(a) [Lp(a)] is a independent genetic risk factor for cardiovascular disease with heritability rates ranging from 70% to 90%. Our study aimed to compare demographic and clinical characteristics in patients with normal vs. abnormal Lp(a).

Methods

We conducted a retrospective chart review at Jacobi Medical Center from August 2020 to September 2023 and we identified 78 patients with available Lp(a) measurement.

Results

Among 78 patients, 32 (41.03%) were female, and 46 (58.97%) were male. 32 patients had abnormal Lp(a) (>75 nmol/L) with a mean of 143.35 nmol/L, mean BMI of 30.34 and median age of 53.5 years. Abnormal Lp(a) correlated with higher LDL levels (111.01 vs. 91.23 mg/dL; p=0.044). Increased Lp(a) was more prevalent among African Americans. No significant association was found between abnormal Lp(a) and aortic or mitral valve calcifications. In the cohort with abnormal Lp(a) levels, the prevalence of heart failure with preserved ejection fraction (HFpEF) was 100%, while the presence of heart failure with reduced ejection was notably lower at 24% (p=0.008). The demographic and clinical characteristics are presented in Table 1.

Conclusions

Our study found no significant difference in comorbidities between both groups but did show a correlation with elevated LDL. HFpEF was more prevalent among patients with abnormal Lp(a).