白细胞介素-6 在阻塞性睡眠呼吸暂停患者的炎症与认知能力之间的潜在作用

IF 3.7 Q2 IMMUNOLOGY
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引用次数: 0

摘要

背景白细胞介素-6(IL-6)是参与炎症反应的主要分子之一,认知障碍或阻塞性睡眠呼吸暂停(OSA)患者的IL-6都可能发生改变。本研究旨在评估严重 OSA(呼吸暂停-低通气指数 - AHI >30/h)患者的血清 IL-6 水平和认知能力。所有患者都接受了睡眠医学访谈,包括埃普沃思嗜睡量表(ESS)、心肺记录仪、蒙特利尔认知评估(MoCA),并抽取血样进行血清 IL-6 评估。此外,OSA 患者的 MoCA(Md = 27.00)和 ESS 评分(Md = 8.00)分别低于对照组(Md = 30.00,p < 0.001;Md = 4.00,p = 0.004)。本研究记录了以较高的 IL-6 血清水平为特征的炎症与 OSA 患者夜间低氧血症和认知功能障碍之间的关系。因此,IL-6水平的升高可能是间歇性夜间低氧导致的血管损伤和神经炎症的结果,并进一步导致OSA患者的神经认知功能障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The potential role of interleukin-6 in the association between inflammation and cognitive performance in obstructive sleep apnea

Background

Interleukin-6 (IL-6) represents one of the main molecules involved in inflammatory responses, which can be altered in either patients with cognitive impairment or obstructive sleep apnea (OSA). The present study aimed to evaluate serum IL-6 levels and cognitive performance in patients with severe OSA (Apnea-Hypopnea Index - AHI >30/h).

Methods

Thirty patients with severe OSA were compared to 15 controls similar in age, sex, and Body Mass Index. All patients underwent a sleep medicine interview, including the Epworth Sleepiness Scale (ESS), a polygraphic cardiorespiratory recording, the Montreal Cognitive Assessment (MoCA), and a blood sample for serum IL-6 assessment.

Results

OSA patients presented higher IL-6 serum levels (Md = 7.38) than controls (Md = 2.20, p < 0.001). Moreover, OSA patients showed lower MoCA (Md = 27.00) and higher ESS scores (Md = 8.00) than controls (Md = 30.00, p < 0.001; Md = 4.00, p = 0.004, respectively). Higher IL-6 serum levels were associated with lower oxygen saturation parameters and MoCA scores.

Conclusions

This study documented an association between inflammation, featured by higher IL-6 serum levels, and both nocturnal hypoxemia and cognitive impairment in OSA patients. Therefore, the increase in IL-6 levels may represent the result of vascular damage and neuroinflammation due to intermittent nocturnal hypoxia and further causing neurocognitive dysfunction in OSA.
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来源期刊
Brain, behavior, & immunity - health
Brain, behavior, & immunity - health Biological Psychiatry, Behavioral Neuroscience
CiteScore
8.50
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审稿时长
97 days
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