基于芳基取代的异汀类和 2-氯乙炔基 (4-(二甲基氨基)苯基)(2-肼基-2-氧代乙基)膦酸酯的杂化化合物的合成与抗肿瘤活性

IF 0.9 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2024-10-04 DOI:10.1134/S1070363224080085

A. V. Bogdanov, A. A. Ivanova, A. D. Voloshina, R. R. Rakhmatullin, A. V. Samorodov, Z. A. Valiullina, I. D. Krylova, S. V. Bukharov

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引用次数: 0

摘要

通过 5-取代的异汀与 2-氯乙基[4-(二甲基氨基)苯基](2-肼基-2-氧代乙基)膦酸盐（KAPAKh）的缩合反应，合成了新的含磷异汀-3-肼酮。结果表明，这些化合物对十二指肠腺癌（HuTu80）和宫颈上皮样癌（M-HeLa）细胞系具有很高的抗肿瘤活性，而对红细胞和正常人肝细胞的毒性较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis and Antitumor Activity of Hybrid Compounds Based on Aryl-Substituted Isatins and 2-Chloroethynyl (4-(Dimetylamino)phenyl)(2-hydrazinyl-2-oxoethyl)phosphinate

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Synthesis and Antitumor Activity of Hybrid Compounds Based on Aryl-Substituted Isatins and 2-Chloroethynyl (4-(Dimetylamino)phenyl)(2-hydrazinyl-2-oxoethyl)phosphinate

New phosphorus-containing isatin-3-hydrazones were synthesized by the condensation reaction of 5-substituted isatins with 2-chloroethyl [4-(dimethylamino)phenyl](2-hydrazinyl-2-oxoethyl)phosphinate (KAPAKh). The resulting compounds were shown to have high antitumor activity against duodenal adenocarcinoma (HuTu80) and cervical epithelioid carcinoma (M-HeLa) cell lines with low toxicity towards erythrocytes and normal human liver cells.

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.