生精干细胞：核心生物学、定义特征和实用性。

IF 2.7 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Reproduction and Development Pub Date : 2024-10-11 DOI:10.1002/mrd.23777

Tessa Lord, Jon M. Oatley

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引用次数: 0

摘要

生精干细胞（SSCs）的作用为精子的持续生成和细胞毒性损伤或移植后的同系再生奠定了基础。几十年来对啮齿类动物模型的研究积累了有关哺乳动物生精干细胞的核心生物学、形态特征和分子特征的知识。目前正在积极将这些发现转化为人类生育能力保护、改善畜牧业和野生动物保护的实用技术。在此，我们将概述这些方面的历史和现状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Spermatogenic Stem Cells: Core Biology, Defining Features, and Utilities

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Spermatogenic Stem Cells: Core Biology, Defining Features, and Utilities

The actions of spermatogenic stem cells (SSCs) provide the foundation for continual spermatogenesis and regeneration of the cognate lineage following cytotoxic insult or transplantation. Several decades of research with rodent models have yielded knowledge about the core biology, morphological features, and molecular profiles of mammalian SSCs. Translation of these discoveries to utilities for human fertility preservation, improving animal agriculture, and wildlife conservation are actively being pursued. Here, we provide overviews of these aspects covering both historical and current states of understanding.

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来源期刊

Molecular Reproduction and Development 生物-发育生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Molecular Reproduction and Development takes an integrated, systems-biology approach to understand the dynamic continuum of cellular, reproductive, and developmental processes. This journal fosters dialogue among diverse disciplines through primary research communications and educational forums, with the philosophy that fundamental findings within the life sciences result from a convergence of disciplines. Increasingly, readers of the Journal need to be informed of diverse, yet integrated, topics impinging on their areas of interest. This requires an expansion in thinking towards non-traditional, interdisciplinary experimental design and data analysis.