高压氧疗法和局部血红蛋白喷剂联合治疗难愈合伤口的疗效。

IF 1.5 4区 医学 Q3 DERMATOLOGY
Levent Demir
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引用次数: 0

摘要

研究目的本研究探讨了高压氧疗法(HBOT)与局部血红蛋白喷剂相结合治疗难愈合、脱屑型糖尿病足溃疡(DFUs)的效果:方法:研究对象包括难愈合的糖尿病足溃疡患者,溃疡至少有25%脱落或坏死。我们比较了接受标准护理和局部喷洒血红蛋白的 HBOT 的患者(氧气组)与只接受标准个性化伤口护理的同等数量患者(对照组)的结果。血红蛋白 A1C 和 C 反应蛋白的初始值、伤口培养结果和 SINBAD(部位、缺血、神经病变、细菌感染、面积、深度)评分均有记录。如果伤口在 16 周内完全闭合,则视为痊愈:氧气组(21 人)的平均 SINBAD 得分为 5.00±0.89,而对照组(21 人)的平均得分为 4.62±0.80(P=0.155)。16 周后,氧气组 85.7% 的伤口完全恢复,而对照组只有 52.4% 的伤口完全恢复(P=0.02):结论:在这项研究中,氧气组有更多伤口痊愈。将 HBOT 与局部血红蛋白喷剂结合使用可为伤口提供更长时间的供氧,这主要是因为患者每天可接受 90 分钟的 HBOT 治疗。这可确保患者同时从全身和局部供氧中获益。这种综合疗法可有效解决缺氧问题,促进难以愈合伤口的愈合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy of combined hyperbaric oxygen therapy and topical haemoglobin spray in treating hard-to-heal sloughy wounds.

Objective: This study examined the effectiveness of a combination of hyperbaric oxygen therapy (HBOT) and topical haemoglobin spray in treating hard-to-heal, sloughy diabetic foot ulcers (DFUs).

Method: Patients with hard-to-heal DFUs at least 25% sloughy or necrotic were included in the study. We compared the results of patients who received standard of care and HBOT with topical haemoglobin spray (oxygen group) to an equal number of patients who only received standard personalised wound care (control group). The initial values of haemoglobin A1C and C-reactive protein, wound culture results and SINBAD (site, ischaemia, neuropathy, bacterial infection, area, depth) scores were documented. Wounds were considered healed when completely closed within 16 weeks.

Results: The oxygen group (n=21) had a mean SINBAD score of 5.00±0.89, while the control group (n=21) had a mean score of 4.62±0.80 (p=0.155). After 16 weeks, 85.7% of wounds in the oxygen group showed complete recovery, compared with 52.4% in the control group (p=0.02).

Conclusion: In this study, a greater number of wounds in the oxygen group healed. Combining HBOT with topical haemoglobin spray provides oxygenation to the wound for longer, primarily because patients can receive 90 minutes of HBOT daily. This ensures that patients benefit from both systemic and local oxygen. This combination therapy may effectively address the problem of hypoxia and promote healing in hard-to-heal wounds.

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来源期刊
Journal of wound care
Journal of wound care DERMATOLOGY-
CiteScore
2.90
自引率
10.50%
发文量
215
期刊介绍: Journal of Wound Care (JWC) is the definitive wound-care journal and the leading source of up-to-date research and clinical information on everything related to tissue viability. The journal was first launched in 1992 and aimed at catering to the needs of the multidisciplinary team. Published monthly, the journal’s international audience includes nurses, doctors and researchers specialising in wound management and tissue viability, as well as generalists wishing to enhance their practice. In addition to cutting edge and state-of-the-art research and practice articles, JWC also covers topics related to wound-care management, education and novel therapies, as well as JWC cases supplements, a supplement dedicated solely to case reports and case series in wound care. All articles are rigorously peer-reviewed by a panel of international experts, comprised of clinicians, nurses and researchers. Specifically, JWC publishes: High quality evidence on all aspects of wound care, including leg ulcers, pressure ulcers, the diabetic foot, burns, surgical wounds, wound infection and more The latest developments and innovations in wound care through both preclinical and preliminary clinical trials of potential new treatments worldwide In-depth prospective studies of new treatment applications, as well as high-level research evidence on existing treatments Clinical case studies providing information on how to deal with complex wounds Comprehensive literature reviews on current concepts and practice, including cost-effectiveness Updates on the activities of wound care societies around the world.
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