极早产新生儿脐带延迟夹闭与急性肾损伤和两年肾脏预后的关系：早产儿促红细胞生成素神经保护试验（PENUT）的二次分析。

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2024-10-11 DOI:10.1038/s41372-024-02143-7

Henry A. Zapata, Namrata Todurkar, Kristen Favel, Russell L. Griffin, Michelle C. Starr, Jennifer R. Charlton, Ryan M. McAdams, David Askenazi, Tapas Kulkarni, Shina Menon, Cherry Mammen, Matthew W. Harer

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引用次数: 0

摘要

背景：大多数早产儿都会发生脐带延迟夹闭（DCC）：大多数早产儿都会出现脐带延迟夹闭（DCC）：方法：对早产儿促红细胞生成素神经保护试验进行二次分析：早产儿促红细胞生成素神经保护试验的二次分析，对象为妊娠 240/7 周至 276/7 周的新生儿。比较了DCC（产后≥30秒）和早期脐带夹闭（ECC）新生儿的AKI和两年肾脏预后（结果：AKI的发生率和严重程度均低于ECC：DCC组和ECC组的AKI发生率和严重程度没有差异（aOR 1.17 [95%CI 0.76-1.80]）。DCC与白蛋白尿或血压升高之间无明显关联：结论：DCC 与新生儿 AKI 下降无关，但与两年后估计肾小球滤过率 (eGFR) 2 调整后几率升高有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Association of delayed cord clamping with acute kidney injury and two-year kidney outcomes in extremely premature neonates: a secondary analysis of the preterm erythropoietin neuroprotection trial (PENUT)

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Delayed cord clamping (DCC) occurs in most preterm births. Evaluate the association of DCC with acute kidney injury (AKI) and two-year kidney outcomes. Secondary analysis of the Preterm Erythropoietin Neuroprotection Trial of neonates born 240/7 to 276/7 weeks gestation. AKI and two year kidney outcomes were compared in neonates with DCC ( ≥ 30 s after delivery) to those with early cord clamping (ECC) (<30 s after delivery). The incidence and severity of AKI did not differ between the DCC and ECC groups (aOR 1.17 [95%CI 0.76–1.80]). At two years corrected age, DCC was associated with a 4.5-fold increased adjusted odds of estimated glomerular filtration rate (eGFR) <90 mL/min/1.73m2. No significant associations were noted between DCC and albuminuria or elevated blood pressure. DCC was not associated with decreased neonatal AKI, but was associated with higher adjusted odds of eGFR <90 mL/min/1.73m2 at two years.

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.