日本两家医院 10 年间从临床血液中分离出的 146 株嗜麦芽僵菌对头孢哌酮的敏感性。

IF 3.7 3区医学 Q2 INFECTIOUS DISEASES

European Journal of Clinical Microbiology & Infectious Diseases Pub Date : 2024-12-01 Epub Date: 2024-10-11 DOI:10.1007/s10096-024-04960-2

Takashi Sakoh, Emiko Miyajima, Yusuke Endo, Masaru Baba, Mizuki Haraguchi, Masayo Morishima, Sho Ogura, Muneyoshi Kimura, Hideki Araoka

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引用次数: 0

摘要

以前关于嗜麦芽酵母菌对头孢克洛的敏感性的报道包括大量非侵袭性或定植的分离株，而关于侵袭性嗜麦芽酵母菌株的数据仍然缺乏。我们回顾性地调查了日本两家医院中引起菌血症的嗜麦芽单胞菌菌株对头孢哌酮的敏感性。其 MIC50 和 MIC90 分别为 0.06 μg/mL 和 0.25 μg/mL，药敏率为 99.3%（现行 CLSI 断点标准）。我们的研究结果提供了日本嗜麦芽糖酵母菌菌株分离的 MIC 分布情况，并显示出嗜麦芽糖酵母菌对头孢哌酮的敏感性在临床侵袭性致病菌株中得以保留。

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Cefiderocol susceptibility of 146 Stenotrophomonas maltophilia strains clinically isolated from blood in two Japanese hospitals over a 10-year period.

Previous reports focusing on cefiderocol susceptibility against Stenotrophomonas maltophilia have included a large number of noninvasive or colonized isolates, and data focusing on invasive S. maltophilia strains are still lacking. We retrospectively investigated the cefiderocol susceptibility of stored S. maltophilia strains that caused bacteremia at two Japanese hospitals. The MIC₅₀ and MIC₉₀ were 0.06 μg/mL and 0.25 μg/mL, respectively, while the susceptibility rate was 99.3% (current CLSI breakpoint criteria). Our results provide the MIC distribution of bacteremic S. maltophilia isolates in Japan and show the preserved cefiderocol susceptibility of S. maltophilia among clinically invasive pathogenic strains.

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来源期刊

European Journal of Clinical Microbiology & Infectious Diseases 医学-传染病学

CiteScore

10.40

自引率

2.20%

发文量

138

审稿时长

1 months

期刊介绍： EJCMID is an interdisciplinary journal devoted to the publication of communications on infectious diseases of bacterial, viral and parasitic origin.