加拿大马尼托巴省肝硬化发病率和流行率趋势:基于人口的研究(2010-2019 年)。

IF 3.7 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
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引用次数: 0

摘要

导言和目标:在北美,慢性肝病和肝硬化的负担持续加重。我们试图估算加拿大马尼托巴省肝硬化的发病率和流行率,并评估 2010-2019 年间的趋势变化:我们利用马尼托巴省的行政医疗数据和两种经过验证的病例查找算法进行了一项基于人口的研究。年发病率和患病率是通过使用广义估计方程的广义线性模型进行估算的,并对年龄和性别进行了调整。使用线性趋势回归模型检验了估计值的变化:两种算法估算出的肝硬化患病人数分别为 16 140 人和 29 943 人。经年龄和性别调整后的发病率在研究期间有所上升(从2010年的每10万人149例到264例,到2019年的每10万人177例到388例)。肝硬化发病率每年增加 2-6%,增幅最大(6-8% 95% CI 7-9%,P 结论:这项基于人群的研究强调了肝硬化令人担忧的时间趋势,其特点是每年的发病率和患病率估计值都在上升,尤其是在青壮年和女性中。这些发现突出表明,迫切需要采取包括预防、早期检测、提供高质量医疗保健和公共卫生措施在内的综合战略,以有效应对这一不断升级的健康负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Trends in the incidence and prevalence of cirrhosis in Manitoba, Canada: A population-based study (2010-2019)

Introduction and Objectives

The burden of chronic liver disease and cirrhosis continues to increase in North America. We sought to estimate the incidence and prevalence of cirrhosis in Manitoba, Canada over time and assess changes in trends between 2010-2019.

Material and Methods

We performed a population-based study using Manitoba administrative health care data, and two validated case-finding algorithms. Annual incidence and prevalence rates were estimated using a generalized linear model with generalized estimating equations, adjusting for age and sex. Changes in estimates were tested using linear trend regression models.

Results

Two algorithms estimated the number of prevalent cirrhosis to be 16,140 and 29,943 respectively. The age- and sex-adjusted incidence rates increased over the study (from 149 to 264 cases per 100,000 population in 2010, to 177 to 388 cases per 100,000 population in 2019). Cirrhosis incidence increased annually by 2-6 %, with the largest increase (6-8 % 95 % CI 7-9 %, p <0.0001) in those aged 18-44 years. Irrespective of the algorithm used, females consistently exhibited higher cirrhosis incidence and prevalence compared to males over time (P <0.0001). Prevalence demonstrated an upward trend among all age groups over time for both algorithms (P < 0.0001).

Conclusions

This population-based study highlights concerning temporal trends in cirrhosis, characterized by rising annual incidence and prevalence estimates, particularly among young adults and females. These findings underscore the urgent need for comprehensive strategies that encompass prevention, early detection, and the delivery of high-quality healthcare and public health initiatives to effectively tackle this escalating health burden.
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来源期刊
Annals of hepatology
Annals of hepatology 医学-胃肠肝病学
CiteScore
7.90
自引率
2.60%
发文量
183
审稿时长
4-8 weeks
期刊介绍: Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.
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