使用自组装肽（PuraStat）对吻合口溃疡的影响--多中心病例系列。

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY

ACG Case Reports Journal Pub Date : 2024-10-10 eCollection Date: 2024-10-01 DOI:10.14309/crj.0000000000001535

Veeral M Oza, Nitish Mittal, Charles Winchester, Yousef Fazel, Amar Manvar, Adam Goodman, Mohit Girotra, Harshit S Khara, Shivangi Kothari, Truptesh H Kothari

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引用次数: 0

摘要

吻合口溃疡（又称边缘溃疡）的治疗极具挑战性，尤其是在既有技术失效的情况下。PuraStat 是一种生物相容性合成肽凝胶，适用于胃肠道和血管吻合口的止血。我们的目的是评估 PuraStat 与标准疗法一起用于吻合口溃疡止血的可行性。这是一项多中心病例系列研究，研究对象是应用了 PuraStat 并进行了后续重复内镜检查的成年患者。10 名患者中有 9 人的临床症状有所改善。我们的结论是，PuraStat 是一种帮助吻合口溃疡愈合的有效药物。

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Impact of Using Self-Assembling Peptide (PuraStat) on Anastomotic Ulcers-A Multicenter Case Series.

Treatment of anastomotic ulcers, also known as marginal ulcers, is challenging, especially when established techniques have failed. PuraStat is a biocompatible synthetic peptide gel that is indicated for hemostasis of bleeding in the gastrointestinal tract and vascular anastomoses. We aim to evaluate the feasibility of PuraStat in the setting of nonhealing anastomotic ulcers when used alongside standard therapies. This is a multicenter case series of adult patients who had PuraStat applied with a follow-up repeat endoscopy. Nine out of 10 patients showed clinical improvement. We concluded that PuraStat is an effective agent to aid in healing of anastomotic ulcer.

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来源期刊

ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-

自引率

14.30%

发文量

170

审稿时长

12 weeks

期刊介绍： ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.