天然产物共轭铂和金配合物作为潜在抗肿瘤药物的研究进展

IF 6 2区医学 Q1 CHEMISTRY, MEDICINAL

European Journal of Medicinal Chemistry Pub Date : 2024-10-10 DOI:10.1016/j.ejmech.2024.116956

Meiyu Wang, Fuwei Li, Zhaoran Wang, Lin Lv, Wukun Liu

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引用次数: 0

摘要

癌症是公认的严重疾病，对人类的生命和健康构成重大威胁。铂类药物具有独特的化学特性和明显的抗增殖活性，因此在临床应用中疗效显著。然而，不良副作用和耐药性严重阻碍了铂类药物治疗各种癌症。天然产物（NPs）具有广泛的药理活性，是开发癌症疗法的重要来源。因此，金属与 NPs 的结合是开发新型抗癌药物的一种有吸引力的策略。一些研究表明，金属与 NPs 的结合具有协同增强抗肿瘤活性的效果。在过渡金属方面，对 NP 共轭铂和金配合物的研究成果不断涌现。本文回顾了过去 5 到 10 年间在开发 NP 共轭铂和金配合物方面取得的进展，包括对其化学性质和作用机制的简要介绍，以及对其优点的总结。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Research Progress of Natural Product-Conjugated Platinum and Gold Complexes as Potential Antitumor Agents

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Research Progress of Natural Product-Conjugated Platinum and Gold Complexes as Potential Antitumor Agents

Cancer is widely recognized as a serious disease that poses a significant threat to human life and health. The distinctive chemical properties and pronounced antiproliferative activity of platinum drugs are considered to be responsible for their remarkable efficacy in clinical applications. However, undesirable side effects and resistance have severely hampered the treatment of various types of cancer with platinum-based drugs. Natural products (NPs) exhibit extensive pharmacological activities and represent an important source for developing cancer therapeutics. Therefore, the combination of metals and NPs is an attractive strategy for the development of new anticancer agents. Several studies have indicated that combining metals with NPs has a synergistic enhancement effect in antitumor activity. For transition metals, there has been burgeoning research output investigating NP-conjugated platinum and gold complexes. The present article reviews the progress made over the past 5 to 10 years on the development of NP-conjugated platinum and gold complexes, including a brief introduction to their chemistry and mechanism of action, and a summary of their benefits.

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来源期刊

European Journal of Medicinal Chemistry 化学-医药化学

CiteScore

11.70

自引率

9.00%

发文量

863

审稿时长

29 days

期刊介绍： The European Journal of Medicinal Chemistry is a global journal that publishes studies on all aspects of medicinal chemistry. It provides a medium for publication of original papers and also welcomes critical review papers. A typical paper would report on the organic synthesis, characterization and pharmacological evaluation of compounds. Other topics of interest are drug design, QSAR, molecular modeling, drug-receptor interactions, molecular aspects of drug metabolism, prodrug synthesis and drug targeting. The journal expects manuscripts to present the rational for a study, provide insight into the design of compounds or understanding of mechanism, or clarify the targets.