Simple physical organic model to predict mechanochemical bond-breaking

Mechanochemical force can pull apart specific bonds, an action that is crucial for efficient and selective chemical transformations. Predicting chemical reactivity under tension force unlocks the selective bond cleavage reaction using ultrasonic irradiation. In this issue of Chem, Craig, Kulik, Moore, and colleagues developed an intuitive physical organic model to understand and predict the chemical reactivity of carbon-carbon bonds under tension.