Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner

Molecular Neurodegeneration (2024) 19:18

https://doi.org/10.1186/s13024-023-00700-w

The original article erroneously presents incorrect graph labels in the caption of Fig. 4. The corrected Fig. 4 caption alongside its respective figure can be viewed ahead in this Correction article.

Fig. 4

GV-971 modifies cytokine and chemokine levels in peripheral blood and cortical tissues. (a) Quantification of cytokine and chemokine concentrations in the serum of APPPS1-21 male mice treated with 160mg/kg GV-971 or vehicle from the University of Chicago (n = 10–11). (b) Quantification of cytokine and chemokine concentrations in the serum of APPPS1-21 female mice treated with 160mg/kg GV-971 or vehicle (n = 8–10). (c) Quantification of cytokine and chemokine concentrations in the serum of 5XFAD male mice treated with 100mg/kg GV-971 or vehicle from Washington University in St. Louis (n = 12–13). (d) Quantification of cytokine and chemokine concentrations in the serum of 5XFAD female mice treated with 100mg/kg GV-971 or vehicle (n = 9–12). (e) Quantification of cytokine and chemokine concentrations in the cortical tissue of 5XFAD male mice treated with 100mg/kg GV-971 or vehicle (n = 12–13). Data presented as SEM. Significance determined using unpaired t-test. *, P<0.05; **, P<0.01; ***, P<0.001; ****, P<0.0001

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Author notes

1. Megan E. Bosch and Hemraj B. Dodiya contributed equally to this work.

2. Julia Michalkiewicz, Choonghee Lee and Shabana M. Shaik contributed equally to this work.

Authors and Affiliations

1. Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer’s Disease Research Center, Washington University in St. Louis, St. Louis, USA

   Megan E. Bosch, Choonghee Lee, Aishwarya Nambiar, Samira Parhizkar & David M. Holtzman

2. Department of Neurobiology, University of Chicago, Chicago, USA

   Hemraj B. Dodiya, Julia Michalkiewicz, Shabana M. Shaik, Ian Q. Weigle, Jack Osborn, Xiaoqiong Zhang & Sangram S. Sisodia

3. Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

   Can Zhang, Prasenjit Mondal, Ashley Gomm & Rudolph E. Tanzi

4. Center for Genetic Medicine, Northwestern University, Chicago, USA

   Priyam Patel & Matthew John Schipma

5. Genome Technology Access Center, Washington University in St. Louis, St. Louis, USA

   Marie L. Laury

6. Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

   Dania Mallah & Oleg Butovsky

7. Department Medicine, Section of Gastroenterology, Hepatology, and Nutrition, The University of Chicago, Chicago, USA

   Eugene B. Chang

8. Department of Pediatrics and Scripps Institution of Oceanography, UCSD, San Diego, USA

   Jack A. Gilbert

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1. Megan E. BoschView author publications

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Correspondence to David M. Holtzman or Sangram S. Sisodia.

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Bosch, M.E., Dodiya, H.B., Michalkiewicz, J. et al. Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner. Mol Neurodegeneration 19, 70 (2024). https://doi.org/10.1186/s13024-024-00764-2

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• Published: 10 October 2024

• DOI: https://doi.org/10.1186/s13024-024-00764-2

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