在温和条件下使用卤化脒盐作为卤素源快速、普遍地获取 α-卤代羰基化合物

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2024-10-09 DOI:10.1002/ejoc.202401111

Lewan Li, Mengxiang Luo, Shuntian Liu, Jian Lv, Jie Zeng, Qiongjiao Yan, Jie Liao, Haifeng Wang, Shuangxi Gu

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引用次数: 0

摘要

以重氮化合物和脒-HX（X = Cl、Br、I）盐为卤素源快速高效地构建α-卤代酮类化合物已被公认为是一种简单实用的策略。该反应具有广泛的范围和可扩展性，因此能够在温和、无金属的条件下，在短时间内合成多种功能协调的 α-卤代酮类化合物。对照实验证实了三酸酯 11 参与了该反应的机理

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Rapid and General Access to α‐Halogenated Carbonyl Compounds Using Amidine Halide Salts as Halogen Sources under Mild Conditions

Rapid and efficient construction of α‐haloketones with diazo compounds and amidine·HX (X = Cl, Br, I) salts as halogen sources has been recognized as a simple and practical strategy. The reaction exhibits a broad scope and scalability, thereby enabling synthesis of a broad spectrum of functionally orchestrated α‐haloketones under mild and metal‐free conditions in a short time. Control experiments established the involvement of triffate 11 in the mechanism

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.