X U Yingshan, W U Chunxiao, Y U Wei, Guo Hongji, L U Liming, X U Nenggui, Tang Chunzhi
{"title":"实验性缺血性中风中电针相关脑可塑性的系统回顾和元分析。","authors":"X U Yingshan, W U Chunxiao, Y U Wei, Guo Hongji, L U Liming, X U Nenggui, Tang Chunzhi","doi":"10.19852/j.cnki.jtcm.20240828.008","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To systematically evaluate the role of electroacupuncture in maintaining brain plasticity in ischemic stroke mediated brain damage.</p><p><strong>Methods: </strong>We searched for all relevant trials published through Oct 7, 2022 from seven databases. Metho-dological quality was assessed using the CAMARADES Risk of Bias Tool. A Meta-analysis of comparative effects was performed using Review Manager v.5.3 software.</p><p><strong>Results: </strong>A total of 101 studies involving 2148 animals were included. For most studies, primary outcomes results of the Meta-analysis indicate that EA significantly improved ischemic stroke rat's postsynaptic density thickness [Standardized Mean Difference (<i>SMD</i>) = 1.41, 95% confidence interval (<i>CI</i>) (0.59, 2.23), <i>P =</i> 0.0008], numerical density of synapses [<i>SMD</i> = 1.55, 95% <i>CI</i> (0.48, 2.63), <i>P =</i> 0.005] compared with non-EA-treated. Similarly, EA could improve parts of biomarkers of synapses, neurogenesis, angiogenesis and neurotrophin activity than the control group (<i>P <</i> 0.05).</p><p><strong>Conclusion: </strong>The existing evidence suggests EA regulating ischemic stroke may be through brain plasticity. More rigorous and high quality studies should be conducted in the future.</p>","PeriodicalId":94119,"journal":{"name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","volume":"44 5","pages":"859-870"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462533/pdf/","citationCount":"0","resultStr":"{\"title\":\"Systematic review and Meta-analysis of brain plasticity associated with electroacupuncture in experimental ischemic stroke.\",\"authors\":\"X U Yingshan, W U Chunxiao, Y U Wei, Guo Hongji, L U Liming, X U Nenggui, Tang Chunzhi\",\"doi\":\"10.19852/j.cnki.jtcm.20240828.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To systematically evaluate the role of electroacupuncture in maintaining brain plasticity in ischemic stroke mediated brain damage.</p><p><strong>Methods: </strong>We searched for all relevant trials published through Oct 7, 2022 from seven databases. Metho-dological quality was assessed using the CAMARADES Risk of Bias Tool. A Meta-analysis of comparative effects was performed using Review Manager v.5.3 software.</p><p><strong>Results: </strong>A total of 101 studies involving 2148 animals were included. For most studies, primary outcomes results of the Meta-analysis indicate that EA significantly improved ischemic stroke rat's postsynaptic density thickness [Standardized Mean Difference (<i>SMD</i>) = 1.41, 95% confidence interval (<i>CI</i>) (0.59, 2.23), <i>P =</i> 0.0008], numerical density of synapses [<i>SMD</i> = 1.55, 95% <i>CI</i> (0.48, 2.63), <i>P =</i> 0.005] compared with non-EA-treated. Similarly, EA could improve parts of biomarkers of synapses, neurogenesis, angiogenesis and neurotrophin activity than the control group (<i>P <</i> 0.05).</p><p><strong>Conclusion: </strong>The existing evidence suggests EA regulating ischemic stroke may be through brain plasticity. More rigorous and high quality studies should be conducted in the future.</p>\",\"PeriodicalId\":94119,\"journal\":{\"name\":\"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan\",\"volume\":\"44 5\",\"pages\":\"859-870\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462533/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.19852/j.cnki.jtcm.20240828.008\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.19852/j.cnki.jtcm.20240828.008","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Systematic review and Meta-analysis of brain plasticity associated with electroacupuncture in experimental ischemic stroke.
Objective: To systematically evaluate the role of electroacupuncture in maintaining brain plasticity in ischemic stroke mediated brain damage.
Methods: We searched for all relevant trials published through Oct 7, 2022 from seven databases. Metho-dological quality was assessed using the CAMARADES Risk of Bias Tool. A Meta-analysis of comparative effects was performed using Review Manager v.5.3 software.
Results: A total of 101 studies involving 2148 animals were included. For most studies, primary outcomes results of the Meta-analysis indicate that EA significantly improved ischemic stroke rat's postsynaptic density thickness [Standardized Mean Difference (SMD) = 1.41, 95% confidence interval (CI) (0.59, 2.23), P = 0.0008], numerical density of synapses [SMD = 1.55, 95% CI (0.48, 2.63), P = 0.005] compared with non-EA-treated. Similarly, EA could improve parts of biomarkers of synapses, neurogenesis, angiogenesis and neurotrophin activity than the control group (P < 0.05).
Conclusion: The existing evidence suggests EA regulating ischemic stroke may be through brain plasticity. More rigorous and high quality studies should be conducted in the future.
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