解码细胞因子标记物与认知的矛盾联系：生理学、炎症和阿尔茨海默病相关认知衰退之间的交叉对话

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-10-06 DOI:10.1016/j.arr.2024.102535

Hiba Khan , Talib Naseem , Pooja Kaushik , Jagriti Narang , Rehan Khan , Siddharth Panwar , Suhel Parvez

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引用次数: 0

摘要

最近的研究通过强调星形胶质细胞、小胶质细胞和免疫细胞在细胞因子信号传导中的关键作用，彻底改变了我们对记忆巩固的理解。细胞因子是一种结构紧凑的蛋白质，在神经元发育、突触传递和正常衰老过程中发挥着关键作用。这篇综述探讨了导致炎症和阿尔茨海默病认知功能衰退的细胞机制，强调了大多数研究的细胞因子（IL-1、IL-6、TNF-α）在大脑功能中的矛盾作用，它们在大脑生理学中是一把双刃剑，既是健康认知功能的促进因素，也是认知功能衰退的潜在因素。

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Decoding paradoxical links of cytokine markers in cognition: Cross talk between physiology, inflammaging, and Alzheimer’s disease- related cognitive decline

Recent research has revolutionized our understanding of memory consolidation by emphasizing the critical role of astrocytes, microglia, and immune cells in through cytokine signaling. Cytokines, compact proteins, play pivotal roles in neuronal development, synaptic transmission, and normal aging. This review explores the cellular mechanisms contributing to cognitive decline in inflammaging and Alzheimer’s disease, highlighting the paradoxical effects of most studied cytokines (IL-1, IL-6, TNF-α) in brain function, which act as a double-edged sword in brain physiology, acting both as facilitators of healthy cognitive function and as a potential contributor to cognitive decline.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.