甲状腺过氧化物酶抗体与中老年人普遍存在的颈动脉内膜中层厚度有关：ELSA-巴西队列。

IF 5.4 2区医学 Q1 Medicine

Journal of Endocrinological Investigation Pub Date : 2024-10-09 DOI:10.1007/s40618-024-02475-3

Vandrize Meneghini, William R Tebar, Itamar S Santos, Carolina C P S Janovsky, Ana C Varella, Paulo A Lotufo, José A Sgarbi, Patrícia F S Teixeira, Isabela M Benseñor

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引用次数: 0

摘要

目的：了解抗甲状腺过氧化物酶抗体（TPOAb）与颈动脉内膜中层厚度（cIMT）之间的关系有助于深入了解甲状腺自身免疫与心血管疾病的关联机制。我们的目的是探讨 ELSA-Brasil 研究参与者的多种 TPOAb 与基线和随访时 cIMT 增加的关系：这项前瞻性队列研究分析了 9264 名无心血管疾病史的参与者（51.5 ± 8.9 岁，55.9% 为女性）的数据。研究人员测定了空腹血清 TPOAb 水平。cIMT 值等于或高于样本平均值的一个偏差标准被归类为基线 cIMT 增高。在排除基线 cIMT 增高的参与者后，计算出 8 年随访后 cIMT 的增高值。使用二元逻辑和泊松回归模型进行了多变量分析：结果：14.3%的参与者在基线时cIMT增大，16.8%的参与者在队列中cIMT增大。在对所有混杂变量进行调整后，TPOAb可检测性（OR = 1.84，95%CI = 1.21-2.79）、低可检测性（OR = 1.81，95%CI = 1.18-2.75）、高可检测性（OR = 2.01，95%CI = 1.29-3.11）和阳性（OR = 1.70，95%CI = 1.07-2.70）TPOAb与基线cIMT增加呈正相关。在排除甲状腺功能障碍患者后，可检测到的低TPOAb和高TPOAb与基线时cIMT增加的关系是一致的。无论是所有样本还是甲状腺功能正常的个体，TPOAb水平与随访时cIMT增加之间都没有统计学意义（P > 0.05）：结论：在研究样本中，不同水平的 TPOAb（包括其可检测性）与基线 cIMT 增加有关。我们强调，将 TPOAb 的可检测性水平视为心血管风险增加的可能标志物可能具有相关性。

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Thyroid peroxidase antibodies were associated with prevalent carotid intima-media thickness in middle-age and older adults: the ELSA-Brasil cohort.

Purpose: Understanding the relationship between antithyroperoxidase antibodies (TPOAb) and carotid intima-media thickness (cIMT) could provide insights into the mechanisms linking thyroid autoimmunity and cardiovascular disease. We aimed to explore the association of multiple categories of TPOAb with the increased cIMT at baseline and at follow-up in participants from the ELSA-Brasil Study.

Methods: This prospective cohort study analyzed data from 9,264 participants (51.5 ± 8.9 years old, 55.9% women) without a history of cardiovascular disease. Fasting serum TPOAb levels were determined. Values of cIMT equal to or above one deviation standard of the sample's mean were classified as increased cIMT at baseline. The increased cIMT after the 8-year follow-up was calculated after excluding participants with increased cIMT at baseline. Multivariate analyses were done using binary logistic and Poisson regression models.

Results: The increased cIMT was prevalent in 14.3% of the participants at baseline and its development occurred in 16.8% participants during the cohort. After adjustment for all confounder variables, TPOAb detectability (OR = 1.84, 95%CI = 1.21-2.79), and low detectable (OR = 1.81, 95%CI = 1.18-2.75), high detectable (OR = 2.01, 95%CI = 1.29-3.11) and positive (OR = 1.70, 95%CI = 1.07-2.70) TPOAb were positively associated with increased cIMT at baseline. The associations of low and high detectable TPOAb and increased cIMT at baseline were consistent when excluding those with thyroid dysfunction. There was no statistically significant association between TPOAb levels and increased cIMT at follow-up (p > 0.05), neither for all sample nor for euthyroid individuals.

Conclusion: Different levels of TPOAb, including its detectability, were associated with increased cIMT at baseline in the studied sample. We highlight that may be relevant to consider the levels of TPOAb detectability as possible marker of increased cardiovascular risk.

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来源期刊

Journal of Endocrinological Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

8.10

自引率

7.40%

发文量

242

期刊介绍： The Journal of Endocrinological Investigation is a well-established, e-only endocrine journal founded 36 years ago in 1978. It is the official journal of the Italian Society of Endocrinology (SIE), established in 1964. Other Italian societies in the endocrinology and metabolism field are affiliated to the journal: Italian Society of Andrology and Sexual Medicine, Italian Society of Obesity, Italian Society of Pediatric Endocrinology and Diabetology, Clinical Endocrinologists’ Association, Thyroid Association, Endocrine Surgical Units Association, Italian Society of Pharmacology.