推进软骨组织工程:三维生物打印方法和生物墨水特性综述。

IF 5.1 2区 医学 Q2 CELL & TISSUE ENGINEERING
Gabriele Boretti, Arsalan Amirfallah, Kyle J Edmunds, Helena Hamzehpour, Ólafur E Sigurjónsson
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引用次数: 0

摘要

关节软骨对人体生理至关重要,其退化对公共卫生构成了重大挑战。虽然三维生物打印和组织工程学的最新进展显示了软骨再生的前景,但研究成果与临床应用之间仍存在差距。本综述批判性地研究了透明软骨的机械和生物特性,以及当前的三维制造方法和分析技术。此外,我们还对软骨组织工程中使用的生物墨水特性进行了定量综述。在对 181 项初步研究进行筛选后,我们对 33 项使用挤压生物打印技术的研究进行了分析和综合,结果表明了机械和生物评估所使用的主要材料、细胞和方法。总之,这篇综述推动了三维生物打印构建物的机械分析和生物材料评估的标准化,以明确其软骨生成潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advancing Cartilage Tissue Engineering: A Review of 3D Bioprinting Approaches and Bioink Properties.

Articular cartilage is crucial in human physiology, and its degeneration poses a significant public health challenge. While recent advancements in 3D bioprinting and tissue engineering show promise for cartilage regeneration, there remains a gap between research findings and clinical application. This review critically examines the mechanical and biological properties of hyaline cartilage, along with current 3D manufacturing methods and analysis techniques. Moreover, we provide a quantitative synthesis of bioink properties used in cartilage tissue engineering. After screening 181 initial works, 33 studies using extrusion bioprinting were analyzed and synthesized, presenting results that indicate the main materials, cells, and methods utilized for mechanical and biological evaluation. Altogether, this review motivates the standardization of mechanical analyses and biomaterial assessments of 3D bioprinted constructs to clarify their chondrogenic potential.

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来源期刊
Tissue Engineering. Part B, Reviews
Tissue Engineering. Part B, Reviews Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
12.80
自引率
1.60%
发文量
150
期刊介绍: Tissue Engineering Reviews (Part B) meets the urgent need for high-quality review articles by presenting critical literature overviews and systematic summaries of research within the field to assess the current standing and future directions within relevant areas and technologies. Part B publishes bi-monthly.
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