A rare case of nodular plaque variant of cutaneous-only Rosai-Dorfman disease: A case report.

Rosai-Dorfman disease (RDD) is a rare benign histiocytic proliferative disorder that classically involves lymph nodes. It often requires histopathological and immunohistochemical confirmation as it can often mimic malignancy on clinical examination and imaging. Treatment recommendations for this disease are widespread, with no clear universal approach. We present a 59-year-old otherwise healthy female with a rapidly growing and therapeutically challenging red-brown nodular plaque on the left cheek, which was consistent with an uncommon plaque-type variant of cutaneous RDD on histopathological evaluation. This case emphasizes the clinical variability of RDD and underscores the importance of histopathological evaluation to help clarify diagnosis, investigations and guide management for patients presenting with unusual clinical variants.