胆石症与心血管疾病发病率之间的关系:系统回顾与元分析》。

IF 1.4 Q4 PHARMACOLOGY & PHARMACY
Rasoul Rahimi, Saeid Heidari-Soureshjani, Catherine M T Sherwin, Karamali Kasiri, Ghorbanali Rahimian
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引用次数: 0

摘要

背景:胆石症(GSD)是导致各种并发症的多因素风险因素:胆石症(GSD)是导致各种并发症的多因素风险因素:本研究旨在通过系统综述和荟萃分析方法研究 GSD 与心血管疾病(CVD)发病率之间的关系:在 Web of Science、Scopus、MEDLINE/PubMed、Cochrane Library 和 Embase 数据库中进行了全面检索。仅纳入 1980 年至 2023 年 12 月间发表的研究。采用Chi-square、I2和森林图评估异质性。Begg's 和 Egger's 检验用于评估发表偏倚。统计显著性以 p 为标准:这项荟萃分析涉及 21 项研究,共有 2 138 282 人参与;发现 GSD 与心血管疾病风险增加之间存在显著关联(相对风险为 1.46,95% 置信区间:1.32-1.63,p 结论:GSD 与心血管疾病风险增加之间存在显著关联:GSD 与心血管疾病发病风险增加之间存在明显关联。采取积极措施对胆石症患者进行有针对性的干预,有可能降低这一人群罹患心血管疾病的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Association between Gallstone Disease and Incidence of Cardiovascular Disease: A Systematic Review and Meta-Analysis.

Background: Gallstone Disease (GSD) is a multifactorial risk factor for various complications.

Objective: This study aimed to examine the relationship between GSD and Cardiovascular Disease (CVD) incidence through a systematic review and meta-analysis approach.

Methods: A thorough search was conducted across Web of Science, Scopus, MEDLINE/PubMed, Cochrane Library, and Embase databases. Only studies published between 1980 and December 2023 were included. Chi-square, I2, and forest plots were used to assess heterogeneity. Begg's and Egger's tests were used to evaluate publication bias. Statistical significance was considered at p <0.05, and all analyses were performed using Stata 17.

Results: This meta-analysis involved 21 studies and comprised 2,138,282 participants; there has been a significant association found between GSD and an increased risk of CVD (with a relative risk of 1.46, 95% confidence interval: 1.32-1.63, p <0.001). The analysis found no evidence of publication bias based on Begg's test (p =0.085) and Egger's test (p =0.231). Subgroup analysis of the studies showed a higher risk of CVD in studies with a sample size of less than 10,000 participants, conducted in 2016 or later, utilizing a cross-sectional design, in Asian countries; the analysis had a moderate quality score, with a follow-up period of equal to or less than ten years.

Conclusion: There has been a significant association found between GSD and an increased risk of incidence of CVD. Taking proactive steps to implement targeted interventions for individuals with gallstone disease could potentially reduce the risk of cardiovascular disease within this population.

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来源期刊
Reviews on recent clinical trials
Reviews on recent clinical trials PHARMACOLOGY & PHARMACY-
CiteScore
3.10
自引率
5.30%
发文量
44
期刊介绍: Reviews on Recent Clinical Trials publishes frontier reviews on recent clinical trials of major importance. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: important Phase I – IV clinical trial studies, clinical investigations at all stages of development and therapeutics. The journal is essential reading for all researchers and clinicians involved in drug therapy and clinical trials.
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