中国人群 T2DM 发病过程中β细胞功能障碍的临床研究进展。

IF 6.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Yibing Chen, Qian Jiang, Xiaowei Xing, Tao Yuan, Pingping Li
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引用次数: 0

摘要

过去 40 年间,中国 2 型糖尿病(T2DM)的患病率增长了 10 倍以上,目前已成为世界上 T2DM 人数最多的国家。胰岛素抵抗和β细胞功能障碍是T2DM的典型特征。虽然这两个因素都起作用,但β细胞功能和β细胞质量下降是T2DM进展的主要因素。考虑到中国 T2DM 患者与其他种族患者之间的差异,研究中国患者在 T2DM 进展过程中的β细胞功能障碍具有重要意义。在此,我们回顾了有关中国人群中 β 细胞功能与 T2DM 进展之间关系的研究,并讨论了不同种族个体之间的差异。同时,我们总结了中国人 T2DM 的危险因素和目前的治疗方法,并讨论了它们对 β 细胞功能的影响,希望能找到更好的 T2DM 治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical research progress on β-cell dysfunction in T2DM development in the Chinese population.

The prevalence of type-2 diabetes mellitus (T2DM) has increased over 10-fold in the past 40 years in China, which now has the largest T2DM population in the world. Insulin resistance and β-cell dysfunction are the typical features of T2DM. Although both factors play a role, decreased β-cell function and β-cell mass are the predominant factors for progression to T2DM. Considering the differences between Chinese T2DM patients and those of other ethnicities, it is important to characterize β-cell dysfunction in Chinese patients during T2DM progression. Herein, we reviewed the studies on the relationships between β-cell function and T2DM progression in the Chinese population and discussed the differences among individuals of varying ethnicities. Meanwhile, we summarized the risk factors and current treatments of T2DM in Chinese individuals and discussed their impacts on β-cell function with the hope of identifying a better T2DM therapy.

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来源期刊
Reviews in Endocrine & Metabolic Disorders
Reviews in Endocrine & Metabolic Disorders 医学-内分泌学与代谢
CiteScore
14.70
自引率
1.20%
发文量
75
审稿时长
>12 weeks
期刊介绍: Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.
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