大卫-加伯斯和哺乳动物精子中 cAMP 生物学的诞生。

IF 2.7 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Reproduction and Development Pub Date : 2024-10-09 DOI:10.1002/mrd.23773

Pablo E. Visconti, Lonny R. Levin, Jochen Buck

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引用次数: 0

摘要

戴维-加伯斯博士对科学做出了许多有影响的贡献，极大地提高了我们对精子生物学的认识。在这篇综述中，我们将重点介绍他发现第二信使 cAMP 在哺乳动物精子中的关键作用。作为一名研究生，大卫发现精子受精所必需的精子运动受控于（当时）最新发现的典型第二信使 cAMP。时至今日，人们正在研究能关闭精子产生 cAMP 的能力并阻止精子运动的药剂，以作为男性和女性的潜在非激素避孕药。如果这些努力获得成功，戴夫的发现将被证明是人类健康革命的火花。

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David Garbers and the Birth of cAMP Biology in Mammalian Sperm

Dr. David Garbers made many impactful contributions to science and vastly improved our understanding of sperm biology. In this review, we focus on his identification of a key role for the second messenger cAMP in mammalian sperm. As a graduate student David discovered that sperm motility, which is essential for sperm to fertilize the egg, is under the control of the (at the time) recently identified, prototypical second messenger cAMP. Fast-forwarding to the present, agents which turn off sperm's ability to generate cAMP and block sperm motility are being investigated as potential nonhormonal contraceptives for men and women. Should these efforts prove successful, Dave's discoveries will prove to be the spark which ignited a revolution in human health.

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来源期刊

Molecular Reproduction and Development 生物-发育生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Molecular Reproduction and Development takes an integrated, systems-biology approach to understand the dynamic continuum of cellular, reproductive, and developmental processes. This journal fosters dialogue among diverse disciplines through primary research communications and educational forums, with the philosophy that fundamental findings within the life sciences result from a convergence of disciplines. Increasingly, readers of the Journal need to be informed of diverse, yet integrated, topics impinging on their areas of interest. This requires an expansion in thinking towards non-traditional, interdisciplinary experimental design and data analysis.