三级淋巴结构的形成：肿瘤-免疫共同进化问题。

IF 3.2 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular immunology Pub Date : 2024-10-09 DOI:10.1016/j.molimm.2024.09.012

Anne M. van der Leun

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引用次数: 0

摘要

人类肿瘤的免疫构成在癌症进展过程中是动态的。然而，究竟是哪些因素推动了肿瘤免疫格局的时空变化，目前还不为人所知。在第3期《细胞报告医学》（Cell Reports Medicine）上，Liu、You、Lan和Ren等人证明了三级淋巴结构（TLSs）的发展是一个循序渐进的过程，与肺腺癌（LUAD）患者的肿瘤进展同时发生。

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Tertiary lymphoid structure formation: A matter of tumor-immune co-evolution

The immune make-up of human tumors is dynamic over the course of cancer progression. However, what factors drive spatiotemporal changes in the tumor-immune landscape is not well-known. In issue 3 of Cell Reports Medicine, Liu, You, Lan and Ren et al. demonstrate that the development of tertiary lymphoid structures (TLSs) is a stepwise process that co-occurs with tumor progression in patients with lung adenocarcinoma (LUAD).

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来源期刊

Molecular immunology 医学-免疫学

CiteScore

6.90

自引率

2.80%

发文量

324

审稿时长

50 days

期刊介绍： Molecular Immunology publishes original articles, reviews and commentaries on all areas of immunology, with a particular focus on description of cellular, biochemical or genetic mechanisms underlying immunological phenomena. Studies on all model organisms, from invertebrates to humans, are suitable. Examples include, but are not restricted to: Infection, autoimmunity, transplantation, immunodeficiencies, inflammation and tumor immunology Mechanisms of induction, regulation and termination of innate and adaptive immunity Intercellular communication, cooperation and regulation Intracellular mechanisms of immunity (endocytosis, protein trafficking, pathogen recognition, antigen presentation, etc) Mechanisms of action of the cells and molecules of the immune system Structural analysis Development of the immune system Comparative immunology and evolution of the immune system "Omics" studies and bioinformatics Vaccines, biotechnology and therapeutic manipulation of the immune system (therapeutic antibodies, cytokines, cellular therapies, etc) Technical developments.