推进甲状腺疾病研究：斑马鱼模型的作用和潜力

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2024-10-05 DOI:10.1016/j.lfs.2024.123099

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引用次数: 0

摘要

甲状腺疾病严重影响人类的新陈代谢、心血管功能、骨骼健康和生殖系统，由于其多因素的性质，带来了复杂的挑战。了解其潜在机制和开发新型治疗方法需要适当的模型。斑马鱼具有遗传易感性、生命周期短和生理相关性等特点，已成为研究甲状腺疾病的重要模型。这篇综述全面分析了斑马鱼甲状腺的结构和功能，探讨了它在甲状腺功能减退症、甲状腺功能亢进症和甲状腺癌等甲状腺疾病模型中的应用，并讨论了目前的局限性和可能的改进。此外，它还概述了基于斑马鱼的研究的未来方向，重点是提高该模型与人类甲状腺疾病的相关性及其加快临床疗法开发的潜力。

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Advancing thyroid disease research: The role and potential of zebrafish model

Thyroid disorders significantly affect human metabolism, cardiovascular function, skeletal health, and reproductive systems, presenting a complex challenge due to their multifactorial nature. Understanding the underlying mechanisms and developing novel therapeutic approaches require appropriate models. Zebrafish, with their genetic tractability, short life cycle, and physiological relevance, have emerged as a valuable model for investigating thyroid diseases. This review provides a comprehensive analysis of the zebrafish thyroid gland's structure and function, explores its application in modeling thyroid pathologies such as hypothyroidism, hyperthyroidism, and thyroid cancer, and discusses current limitations and possible improvements. Furthermore, it outlines future directions for zebrafish-based research, focusing on enhancing the model's relevance to human thyroid disease and its potential to expedite the development of clinical therapies.

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.