返回:PNU-74654 可增强 5-FU 对乳腺癌的抗增殖作用,并通过 Wnt 通路拮抗凝血酶诱导的细胞生长。

IF 4.5 2区 生物学 Q2 CELL BIOLOGY
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引用次数: 0

摘要

撤回:F. Rahmani、F. Amerizadeh、S. M. Hassanian、M. Hashemzehi、S.-N.Nasiri, H. Fiuji, G. A. Ferns, M. Khazaei, and A. Avan, "PNU-74654 Enhances the Antiproliferative Effects of 5-FU in Breast Cancer and Antagonizes Thrombin-induced Cell Growth via the Wnt Pathway," Journal of Cellular Physiology 234, no:14123-14132, https://doi.org/10.1002/jcp.28104.上述文章于 2019 年 1 月 11 日在线发表于《威利在线图书馆》(wileyonlinelibrary.com),经期刊主编罗伯特-希思(Robert Heath)与威利期刊有限责任公司(Wiley Periodicals LLC)协商,该文章已被撤回。同意撤稿的原因是第三方对文章中提供的数据提出了疑虑。具体来说,图 1c 中的图像元素以前由同一作者小组在不同的科学背景下发表过。此外,图 3b 中与 "对照组 "和 "5-FU "组相对应的组织学染色面板被发现来自同一生物样本。最后,在图 6b 中发现了剪接位点。作者在提出要求后未能令人满意地解决这些问题。因此,由于编辑对文章中提供的数据及其结论失去了信任,因此需要撤回文章。通讯作者 Majid Khazaei 不同意撤稿决定。其余合著者也未对此予以确认。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
RETRACTION: PNU-74654 enhances the antiproliferative effects of 5-FU in breast cancer and antagonizes thrombin-induced cell growth via the Wnt pathway.

Retraction: F. Rahmani, F. Amerizadeh, S. M. Hassanian, M. Hashemzehi, S.-N. Nasiri, H. Fiuji, G. A. Ferns, M. Khazaei, and A. Avan, "PNU-74654 Enhances the Antiproliferative Effects of 5-FU in Breast Cancer and Antagonizes Thrombin-induced Cell Growth via the Wnt Pathway," Journal of Cellular Physiology 234, no. 8 (2019): 14123-14132, https://doi.org/10.1002/jcp.28104. The above article, published online on 11 January 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Robert Heath; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by a third party on the data presented in the article. Specifically, image elements in Figure 1c were previously published by the same author group in a different scientific context. Additionally, the panels representing the histological staining corresponding to the "Control" and "5-FU" groups in Figure 3b were found to originate from the same biological sample. Finally, splicing sites have been detected within Figure 6b. The concerns were not satisfactorily addressed by the authors upon request. Accordingly, retraction is warranted as the editors have lost trust in the data presented in the article and in its conclusions. The corresponding author Majid Khazaei disagrees with the decision of retraction. No confirmation was obtained by the remaining co-authors.

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来源期刊
CiteScore
14.70
自引率
0.00%
发文量
256
审稿时长
1 months
期刊介绍: The Journal of Cellular Physiology publishes reports of high biological significance in areas of eukaryotic cell biology and physiology, focusing on those articles that adopt a molecular mechanistic approach to investigate cell structure and function. There is appreciation for the application of cellular, biochemical, molecular and in vivo genetic approaches, as well as the power of genomics, proteomics, bioinformatics and systems biology. In particular, the Journal encourages submission of high-interest papers investigating the genetic and epigenetic regulation of proliferation and phenotype as well as cell fate and lineage commitment by growth factors, cytokines and their cognate receptors and signal transduction pathways that influence the expression, integration and activities of these physiological mediators. Similarly, the Journal encourages submission of manuscripts exploring the regulation of growth and differentiation by cell adhesion molecules in addition to the interplay between these processes and those induced by growth factors and cytokines. Studies on the genes and processes that regulate cell cycle progression and phase transition in eukaryotic cells, and the mechanisms that determine whether cells enter quiescence, proliferate or undergo apoptosis are also welcomed. Submission of papers that address contributions of the extracellular matrix to cellular phenotypes and physiological control as well as regulatory mechanisms governing fertilization, embryogenesis, gametogenesis, cell fate, lineage commitment, differentiation, development and dynamic parameters of cell motility are encouraged. Finally, the investigation of stem cells and changes that differentiate cancer cells from normal cells including studies on the properties and functions of oncogenes and tumor suppressor genes will remain as one of the major interests of the Journal.
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