过敏和哮喘中的分子生物学。

IF 11.4 1区 医学 Q1 ALLERGY
Hirohisa Saito, Masato Tamari, Kenichiro Motomura, Masashi Ikutani, Susumu Nakae, Kenji Matsumoto, Hideaki Morita
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引用次数: 0

摘要

本综述探讨了近年来omics技术对过敏和哮喘研究的变革性影响,重点关注与基因组学和转录组学相关的高通量技术的进展。尤其是单细胞 RNA 测序技术的迅速普及极大地促进了我们对过敏性疾病分子病理学的了解。此外,高通量基因组测序加速了单基因疾病的发现,而这些疾病以前被忽视为普通的难治性过敏性疾病。我们还介绍了微生物组学、蛋白质组学、脂质组学和代谢组学,这些领域的研究兴趣正在迅速增长,尽管它们目前的许多研究结果还不能作为确凿的证据。通过整合这些 omics 数据,我们将对疾病机制有更深入的了解,从而开发出有望提高治疗效果的精准医疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Omics in allergy and asthma.

This review explores the transformative impact of omics technologies on allergy and asthma research in recent years, focusing on advancements in high-throughput technologies related to genomics and transcriptomics. In particular, the rapid spread of single-cell RNA sequencing has markedly advanced our understanding of the molecular pathology of allergic diseases. Furthermore, high-throughput genome sequencing has accelerated the discovery of monogenic disorders that were previously overlooked as ordinary intractable allergic diseases. We also introduce microbiomics, proteomics, lipidomics, and metabolomics, which are quickly growing areas of research interest, although many of their current findings remain inconclusive as solid evidence. By integrating these omics data, we will gain deeper insights into disease mechanisms, leading to the development of precision medicine approaches that promise to enhance treatment outcomes.

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来源期刊
CiteScore
25.90
自引率
7.70%
发文量
1302
审稿时长
38 days
期刊介绍: The Journal of Allergy and Clinical Immunology is a prestigious publication that features groundbreaking research in the fields of Allergy, Asthma, and Immunology. This influential journal publishes high-impact research papers that explore various topics, including asthma, food allergy, allergic rhinitis, atopic dermatitis, primary immune deficiencies, occupational and environmental allergy, and other allergic and immunologic diseases. The articles not only report on clinical trials and mechanistic studies but also provide insights into novel therapies, underlying mechanisms, and important discoveries that contribute to our understanding of these diseases. By sharing this valuable information, the journal aims to enhance the diagnosis and management of patients in the future.
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