2013-2016年多中心回顾性队列研究:早发子痫前期/妊娠高血压可能与妊娠28-31周出生的单胎极低出生体重儿3岁时脑瘫的低发病率有关(EOPE-DQ研究)。

IF 4.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE
Akihide Ohkuchi, Hirotada Suzuki, Asako Kanai, Masashi Fukuda, Yoshinori Takeda, Chiho Fuseya, Makoto Nomiyama, Takafumi Ushida, Kazushi Watanabe, Yumi Kono, Katsuhiko Naruse, Hiroyuki Seki, Shigeru Saito
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引用次数: 0

摘要

我们的目的是评估任何类型的妊娠高血压疾病(HDP)对妊娠24-31周出生的单胎超低出生体重儿(VLBW)3岁时出现脑瘫(CP)或发育迟缓(DD)的影响。这是一项回顾性队列研究,研究对象是2013-2016年在日本出生的24-31周VLBW婴儿,研究使用了全国产科数据库和日本新生儿研究网络(NRNJ)数据库,并对合并HDP的妇女进行了二次调查(EOPE-DQ研究)。在 7 个三级中心的 529 名长期随访对象中,3 岁时接受 CP 随访的比例为 56.1%,3 岁时接受 DD 随访的比例为 54.1%。患 CP 的婴儿出现 PE/SPE/GH 的比例明显低于对照组(1/22 [4.5%] vs. 66/274 [24.1%],P = 0.034);尤其是在 28-31 周出生的婴儿中,患 CP 的婴儿出现 PE/SPE/GH 的比例明显低于对照组(0/13 [0%] vs. 44/151 [29.1%],P = 0.021)。患有 DD 的婴儿与对照组的 PE/SPE/GH 百分比没有差异(9/49 [18.4%] vs. 54/237 [22.8%],p = 0.574)。综合风险因素(月龄后36周时支气管肺发育不良、脑室内出血、缺氧缺血性脑病、败血症、坏死性小肠结肠炎或室周白斑)在DD婴儿中所占的比例明显高于对照组。总之,30 周左右的 PE/SPE/GH 可能与 CP 的低发病率有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Early-onset preeclampsia/gestational hypertension may be associated with a low incidence of cerebral palsy at 3 years old in singleton very low-birth-weight infants born at 28-31 weeks of gestation (EOPE-DQ study): a multi-center retrospective cohort study in 2013-2016.

Our aim was to evaluate the effects of any types of hypertensive disorders of pregnancy (HDP) on the development of either cerebral palsy (CP) or developmental delay (DD) at 3 years old in singleton very low-birth-weight (VLBW) infants born at 24-31 weeks of gestation. This was a retrospective cohort study of VLBW infants born at 24-31 weeks in 2013-2016 in Japan, using a nationwide obstetrical database, and Neonatal Research Network Japan (NRNJ) Database, accompanied by a secondary survey of women complicated with HDP (EOPE-DQ study). In 529 candidates for long-term follow-up in 7 tertiary centers, the percentage undergoing follow-up for CP at 3 years old was 56.1%, and the percentage receiving follow-up for DD at 3 years old was 54.1%. The percentage of PE/SPE/GH was significantly lower in infants with CP than in controls (1/22 [4.5%] vs. 66/274 [24.1%], p = 0.034); especially, in infants born at 28-31 weeks, the percentage of PE/SPE/GH was significantly lower in infants with CP than in controls (0/13 [0%] vs. 44/151 [29.1%], p = 0.021). The percentage of PE/SPE/GH was not different between infants with DD and controls (9/49 [18.4%] vs. 54/237 [22.8%], p = 0.574). The percentage of composite risk factors (either bronchopulmonary dysplasia at a postmenstrual age of 36 weeks, intraventricular hemorrhage, hypoxic ischemic encephalopathy, sepsis, necrotizing enterocolitis, or periventricular leukomalacia) was significantly higher in infants with DD than in controls. In conclusion, PE/SPE/GH around 30 weeks may be associated with a low incidence of CP.

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来源期刊
Hypertension Research
Hypertension Research 医学-外周血管病
CiteScore
7.40
自引率
16.70%
发文量
249
审稿时长
3-8 weeks
期刊介绍: Hypertension Research is the official publication of the Japanese Society of Hypertension. The journal publishes papers reporting original clinical and experimental research that contribute to the advancement of knowledge in the field of hypertension and related cardiovascular diseases. The journal publishes Review Articles, Articles, Correspondence and Comments.
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