脊髓空洞症患者的长期死亡结果和死亡预测因素。

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Clinical Neurology and Neurosurgery Pub Date : 2024-10-02 DOI:10.1016/j.clineuro.2024.108577

Sahin Kenan Deniz , Hatice Turgut , Fatih Deveci̇ , Hüseyin Kaya , Ismail Kursad Gokce , Ramazan Ozdemir , Selami Cagatay Onal

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引用次数: 0

摘要

目的：尽管医疗技术不断进步，脊髓膜膨出症仍是导致死亡和残疾的主要原因。本研究旨在分析影响死亡率的因素，并提出降低死亡率的方法：我们回顾了 2010 年 1 月至 2021 年 12 月期间接受脊髓空洞症手术的 173 名患者。影响死亡率的变量分为患者相关因素和间接相关因素。数据通过患者档案回顾和与家长的电话访谈收集：死亡率受多种因素影响：女性（增加 3.2 倍）、截瘫（增加 3.1 倍）、未进行系带松解手术（增加 9.4 倍）、脊柱侧弯（增加 4.2 倍）和肾功能衰竭（增加 5.28 倍）。缺陷大小和父亲的教育水平也对死亡率有显著影响。总死亡率为 20.8%，脑积水是主要原因：结论：髓母细胞瘤患者的死亡率和残疾率居高不下，其中超过 50% 的死亡是可以预防的。有效的治疗可大大提高死亡率。长期研究对于推进这一领域的研究至关重要。

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Long-term mortality outcomes and mortality predictors in patients with myelomeningocele

Objective

Despite advances, myelomeningocele remains a major cause of mortality and disability. This study aims to analyze factors influencing mortality and suggest ways to reduce it.

Methods

We reviewed 173 patients who underwent surgery for myelomeningocele from January 2010 to December 2021. Variables affecting mortality were categorized into patient-related and indirectly related factors. Data were collected through patient file reviews and phone interviews with parents.

Results

Mortality is influenced by multiple factors: female gender (3.2-fold increase), paraplegia (3.1-fold increase), absence of tethered cord release surgery (9.4-fold increase), scoliosis (4.2-fold increase), and renal failure (5.28-fold increase). Defect size and father's education level also significantly impact mortality. The overall mortality rate was 20.8 %, with hydrocephalus being the leading cause.

Conclusion

Mortality and disability in myelomeningocele patients remain high, with over 50 % of deaths being preventable. Effective management could significantly improve mortality rates. Long-term studies are crucial for advancing research in this field.

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来源期刊

Clinical Neurology and Neurosurgery 医学-临床神经学

CiteScore

3.70

自引率

5.30%

发文量

358

审稿时长

46 days

期刊介绍： Clinical Neurology and Neurosurgery is devoted to publishing papers and reports on the clinical aspects of neurology and neurosurgery. It is an international forum for papers of high scientific standard that are of interest to Neurologists and Neurosurgeons world-wide.