开发高附加值化合物的生物催化剂。

IF 1.4 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Atsushi Usami
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引用次数: 0

摘要

高附加值化合物(如单萜类化合物)是重要的工业目标,因为它们是制药和工业应用中不可或缺的一类化合物。同时,自然资源的枯竭和气候变化要求采用可持续的生产方法。近年来,生物催化法作为传统方法的一种可能替代方法,吸引了研究人员的关注,它可以在温和的条件下通过区域和立体选择性反应进行微生物生物生产。在这篇微型综述中,我们重点介绍了非模式微生物 Acinetobacter sp. Tol 5 利用具有代表性的单萜类化合物香叶醇的生物转化途径的鉴定,以及高附加值单萜类化合物 (E)-geranic acid 的非常规生物生产方法的构建,该方法具有巨大的工业应用潜力。该方法提供了一种更环保的方法,并有助于优化高附加值化合物的生物转化和生物生产策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development of biocatalysts for high-value-added compounds.

High-value-added compounds, such as monoterpenoids, are an important industrial targets because they are an essential group of compounds for pharmaceutical and industrial applications. Meanwhile, the depletion of natural resources and climate change demands sustainable production methods. In recent years, biocatalysis, which allows microbial bioproduction by regio- and stereo-selective reaction under mild conditions, has been attracted researchers' attention as a possible alternative to conventional methods. In this mini-review, we focus on the identification of biotransformation pathways in the non-model microorganism Acinetobacter sp. Tol 5 using geraniol, a representative monoterpenoid, and on the construction of an unconventional bioproduction method for high-value-added monoterpenoid (E)-geranic acid, which has great potential for industrial applications. This method offers a more environmentally friendly approach and insights contribute to optimizing biotransformation and bioproduction strategies for high-value-added compounds.

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来源期刊
Bioscience, Biotechnology, and Biochemistry
Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
183
审稿时长
1 months
期刊介绍: Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).
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