Wencai Wang, Menghao Liu, Zun Wang, Luyao Ma, Yongqiang Zhao, Wei Ye, Xianfeng Li
{"title":"缺血性中风、冠心病和脑积水之间因果关系的双向孟德尔随机研究","authors":"Wencai Wang, Menghao Liu, Zun Wang, Luyao Ma, Yongqiang Zhao, Wei Ye, Xianfeng Li","doi":"10.1002/brb3.70090","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>The association among coronary heart disease, ischemic stroke, and hydrocephalus remains ambiguous.</p>\n </section>\n \n <section>\n \n <h3> Objectives</h3>\n \n <p>There is a need for a Mendelian randomization study to evaluate the underlying causality between coronary heart disease, ischemic stroke, and hydrocephalus.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The data source utilized genome-wide association studies, employing a threshold of <i>p </i>< 5 × 10<sup>−8</sup> to identify single nucleotide polymorphisms strongly linked to ischemic stroke and coronary heart disease as instrumental variables (IVs). Five methods—inverse variance weighted (IVW), Mendelian randomization (MR) Egger, Weighted Median, Weighted mode, and Simple mode—utilized the selected IVs to estimate the causality between ischemic stroke, coronary heart disease, and hydrocephalus.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The IVW demonstrated that ischemic stroke and coronary heart disease serve as risk factors for hydrocephalus (odds ratio [OR] = 1.650, 95% CI: 1.066–2.554, <i>p</i> = 0.025; OR = 1.307, 95% CI: 1.023–1.668, <i>p</i> = 0.032). Both the MR-Egger intercept test and Cochran's <i>Q</i> test affirmed the relative reliability of the IVW analysis results. However, no evidence of a reverse causation was observed between hydrocephalus and coronary heart disease or ischemic stroke.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Coronary heart disease and Ischemic stroke may increase the risk of hydrocephalus.</p>\n </section>\n </div>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460635/pdf/","citationCount":"0","resultStr":"{\"title\":\"A Bidirectional Mendelian Randomization Study of the Causal Association Between Ischemic Stroke, Coronary Heart Disease, and Hydrocephalus\",\"authors\":\"Wencai Wang, Menghao Liu, Zun Wang, Luyao Ma, Yongqiang Zhao, Wei Ye, Xianfeng Li\",\"doi\":\"10.1002/brb3.70090\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>The association among coronary heart disease, ischemic stroke, and hydrocephalus remains ambiguous.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>There is a need for a Mendelian randomization study to evaluate the underlying causality between coronary heart disease, ischemic stroke, and hydrocephalus.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>The data source utilized genome-wide association studies, employing a threshold of <i>p </i>< 5 × 10<sup>−8</sup> to identify single nucleotide polymorphisms strongly linked to ischemic stroke and coronary heart disease as instrumental variables (IVs). Five methods—inverse variance weighted (IVW), Mendelian randomization (MR) Egger, Weighted Median, Weighted mode, and Simple mode—utilized the selected IVs to estimate the causality between ischemic stroke, coronary heart disease, and hydrocephalus.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The IVW demonstrated that ischemic stroke and coronary heart disease serve as risk factors for hydrocephalus (odds ratio [OR] = 1.650, 95% CI: 1.066–2.554, <i>p</i> = 0.025; OR = 1.307, 95% CI: 1.023–1.668, <i>p</i> = 0.032). Both the MR-Egger intercept test and Cochran's <i>Q</i> test affirmed the relative reliability of the IVW analysis results. However, no evidence of a reverse causation was observed between hydrocephalus and coronary heart disease or ischemic stroke.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Coronary heart disease and Ischemic stroke may increase the risk of hydrocephalus.</p>\\n </section>\\n </div>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460635/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/brb3.70090\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"102","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/brb3.70090","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
A Bidirectional Mendelian Randomization Study of the Causal Association Between Ischemic Stroke, Coronary Heart Disease, and Hydrocephalus
Background
The association among coronary heart disease, ischemic stroke, and hydrocephalus remains ambiguous.
Objectives
There is a need for a Mendelian randomization study to evaluate the underlying causality between coronary heart disease, ischemic stroke, and hydrocephalus.
Methods
The data source utilized genome-wide association studies, employing a threshold of p < 5 × 10−8 to identify single nucleotide polymorphisms strongly linked to ischemic stroke and coronary heart disease as instrumental variables (IVs). Five methods—inverse variance weighted (IVW), Mendelian randomization (MR) Egger, Weighted Median, Weighted mode, and Simple mode—utilized the selected IVs to estimate the causality between ischemic stroke, coronary heart disease, and hydrocephalus.
Results
The IVW demonstrated that ischemic stroke and coronary heart disease serve as risk factors for hydrocephalus (odds ratio [OR] = 1.650, 95% CI: 1.066–2.554, p = 0.025; OR = 1.307, 95% CI: 1.023–1.668, p = 0.032). Both the MR-Egger intercept test and Cochran's Q test affirmed the relative reliability of the IVW analysis results. However, no evidence of a reverse causation was observed between hydrocephalus and coronary heart disease or ischemic stroke.
Conclusions
Coronary heart disease and Ischemic stroke may increase the risk of hydrocephalus.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
