真菌免疫和疫苗考虑因素

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2024-10-09 DOI:10.1016/j.chom.2024.09.011

Alexander J. Whitehead, Therese Woodring, Bruce S. Klein

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引用次数: 0

摘要

真菌病对公共健康的威胁日益严重，而我们目前的抗真菌疗法还不能很好地应对这一威胁。随着免疫力低下的宿主群体不断扩大，以及生态环境的变化有利于真菌病原体的出现，开发包括疫苗在内的新型抗真菌药物已成为全球的当务之急。在此，我们总结了对真菌致病机理认识的最新进展、宿主抗真菌免疫反应的关键特征，以及如何利用这些发现设计新型方法来治疗致命的真菌疾病。

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Immunity to fungi and vaccine considerations

Fungal disease poses a growing threat to public health that our current antifungal therapies are not well equipped to meet. As the population of immunocompromised hosts expands, and ecological changes favor the emergence of fungal pathogens, the development of new antifungal agents, including vaccines, becomes a global priority. Here, we summarize recent advancements in the understanding of fungal pathogenesis, key features of the host antifungal immune response, and how these findings could be leveraged to design novel approaches to deadly fungal disease.

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.