儿童麻醉与自闭症风险:人群和小鼠研究。

IF 4.1 Q1 CLINICAL NEUROLOGY
Brain communications Pub Date : 2024-09-24 eCollection Date: 2024-01-01 DOI:10.1093/braincomms/fcae325
Mingyang Sun, Ningning Fu, Ting Li, Mengrong Miao, Wan-Ming Chen, Szu-Yuan Wu, Jiaqiang Zhang
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引用次数: 0

摘要

在临床前研究中,儿童早期接触全身麻醉与婴儿大脑形态和行为的潜在变化有关,从而导致与自闭症谱系障碍有关的长期行为。本研究通过一项基线特征匹配的人群队列研究,调查了儿童早期接触全身麻醉与自闭症风险之间的关联,并利用台湾妇幼保健数据库评估了接触七氟烷对小鼠自闭症样行为的影响。2004年至2014年间至少接触过一次全身麻醉的0-3岁儿童与未接触过全身麻醉的儿童进行了1:1配对。采用风险比和置信区间来评估全身麻醉与自闭症发生之间的关系。此外,小鼠在出生后第5-7天接触七氟醚2小时,并评估了与自闭症有关的行为变化。倾向得分匹配的结果是每组有 7530 名儿童。暴露组和未暴露组的自闭症发病率(IRs)分别为每10万人年11.26例和6.05例。接触全身麻醉后的自闭症发病率比为 1.86(95% 置信区间,1.34-2.59)。在小鼠中,接触七氟醚会诱发类似自闭症的行为,并导致自闭症高风险基因下调,包括ARID1B、GABRA5、GABRB3、GRIN2B、SHANK3和SUV420H1。儿童早期接触全身麻醉与自闭症风险增加有关。小鼠反复接触七氟醚会诱发类似自闭症的行为,这表明麻醉与自闭症的发展之间存在潜在联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Childhood anaesthesia and autism risk: population and murine study.

Early childhood exposure to general anaesthesia has been linked to potential changes in infant brain morphology and behaviour in preclinical studies, contributing to long-term behaviours associated with autism spectrum disorder. This study investigates the association between early childhood exposure to general anaesthesia and the risk of autism, using a population-based cohort study with matching for baseline characteristics and evaluates the effect of sevoflurane exposure on autism-like behaviour in mice, using the Taiwan Maternal and Child Health Database. Children aged 0-3 who received at least one exposure to general anaesthesia between 2004 and 2014 were matched 1:1 with children who were not exposed. Risk ratios and confidence intervals were used to assess the relationship between general anaesthesia and the occurrence of autism. Additionally, mice were exposed to sevoflurane for 2 h on postnatal days 5-7, and changes in behaviour related to autism were evaluated. Propensity score matching resulted in 7530 children in each group. The incidence rates (IRs) of autism were 11.26 and 6.05 per 100 000 person-years in the exposed and unexposed groups, respectively. The incidence ratio for autism following exposure to general anaesthesia was 1.86 (95% confidence interval, 1.34-2.59). In mice, sevoflurane exposure induced autism-like behaviours and led to the downregulation of high-risk autism genes, including ARID1B, GABRA5, GABRB3, GRIN2B, SHANK3 and SUV420H1. Early childhood exposure to general anaesthesia is associated with an increased risk of autism. Repeated exposure to sevoflurane in mice induces autism-like behaviours, suggesting a potential link between anaesthesia and the development of autism.

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