新生儿败血症:新生儿败血症:病因、病理生理学、诊断进展和管理策略》。

IF 1.7 Q2 PEDIATRICS
Clinical Medicine Insights-Pediatrics Pub Date : 2024-09-25 eCollection Date: 2024-01-01 DOI:10.1177/11795565241281337
Adi Raturi, Suresh Chandran
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引用次数: 0

摘要

新生儿败血症是指出生后 28 天内的血液感染,是发展中国家和发达国家婴儿发病和死亡的主要原因。此外,新生儿败血症因其在未成熟的新生儿免疫系统中发展的独特病理生理学和表现因素而与众不同。本综述重点介绍目前对新生儿败血症的机理和影响的认识,全面概述流行病学、病因学、病理生理学、主要风险因素、体征和症状,以及对早发性和晚发性新生儿败血症诊断和管理的最新共识。报告还讨论了新的生物标记物和即将推出的治疗策略,以及 COVID-19 感染发展为婴儿败血症的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neonatal Sepsis: Aetiology, Pathophysiology, Diagnostic Advances and Management Strategies.

Neonatal sepsis, a bloodstream infection in the first 28 days of life, is a leading cause of morbidity and mortality among infants in both developing and developed countries. Additionally, sepsis is distinguished in neonates by unique pathophysiological and presentational factors relating to its development in immature neonatal immune systems. This review focuses on the current understanding of the mechanics and implications of neonatal sepsis, providing a comprehensive overview of the epidemiology, aetiology, pathophysiology, major risk factors, signs and symptoms and recent consensus on the diagnosis and management of both early-onset and late-onset neonatal sepsis. It also includes a discussion on novel biomarkers and upcoming treatment strategies for the condition as well as the potential of COVID-19 infection to progress to sepsis in infants.

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