{"title":"一个罕见的颅内感染 Cladophialophora bantiana 病例：突显新一代测序技术在诊断中的实用性。","authors":"Melissa Whitman, Nicole Vissichelli","doi":"10.1155/2024/8892177","DOIUrl":null,"url":null,"abstract":"<p><p><i>Cladophialophora bantiana</i> is a dematiaceous fungi and the most common cause of cerebral phaeohyphomycosis. Here, we report a rare case of cerebral ventriculitis with development of a cerebral abscess due to <i>C. bantiana</i> diagnosed by cell-free DNA next-generation sequencing. Noninvasive diagnostics led to earlier disease identification and initiation of antifungal therapy, which has the potential to reduce mortality in this highly fatal disease.</p>","PeriodicalId":30327,"journal":{"name":"Case Reports in Transplantation","volume":"2024 ","pages":"8892177"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455592/pdf/","citationCount":"0","resultStr":"{\"title\":\"A Rare Case of <i>Cladophialophora bantiana</i> Intracranial Infection: Highlighting the Utility of Next-Generation Sequencing in Diagnosis.\",\"authors\":\"Melissa Whitman, Nicole Vissichelli\",\"doi\":\"10.1155/2024/8892177\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Cladophialophora bantiana</i> is a dematiaceous fungi and the most common cause of cerebral phaeohyphomycosis. Here, we report a rare case of cerebral ventriculitis with development of a cerebral abscess due to <i>C. bantiana</i> diagnosed by cell-free DNA next-generation sequencing. Noninvasive diagnostics led to earlier disease identification and initiation of antifungal therapy, which has the potential to reduce mortality in this highly fatal disease.</p>\",\"PeriodicalId\":30327,\"journal\":{\"name\":\"Case Reports in Transplantation\",\"volume\":\"2024 \",\"pages\":\"8892177\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455592/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Case Reports in Transplantation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2024/8892177\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Case Reports in Transplantation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2024/8892177","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
Cladophialophora bantiana是一种半知菌类真菌，也是脑皮真菌病最常见的病因。在此，我们报告了一例罕见的脑室炎病例，该病例通过无细胞 DNA 下一代测序确诊为 C. bantiana 引起的脑脓肿。无创诊断有助于更早地识别疾病并开始抗真菌治疗，这有可能降低这种致命疾病的死亡率。
A Rare Case of Cladophialophora bantiana Intracranial Infection: Highlighting the Utility of Next-Generation Sequencing in Diagnosis.
Cladophialophora bantiana is a dematiaceous fungi and the most common cause of cerebral phaeohyphomycosis. Here, we report a rare case of cerebral ventriculitis with development of a cerebral abscess due to C. bantiana diagnosed by cell-free DNA next-generation sequencing. Noninvasive diagnostics led to earlier disease identification and initiation of antifungal therapy, which has the potential to reduce mortality in this highly fatal disease.
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