短链脂肪酸在癌症预防和治疗中的作用。

IF 3.8 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Archives of biochemistry and biophysics Pub Date : 2024-10-04 DOI:10.1016/j.abb.2024.110172

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引用次数: 0

摘要

短链脂肪酸（SCFAs）是肠道中的微生物代谢产物，可能在癌症预防和治疗中发挥作用。它们影响正常细胞和癌细胞的新陈代谢，调节各种细胞能量代谢过程。SCFAs 还能抑制组蛋白去乙酰化酶，而组蛋白去乙酰化酶是癌症治疗的靶点。三种主要的 SCFAs 是醋酸酯、丙酸酯和丁酸酯，它们通过特定的转运体被转运到细胞中。SCFAs 可增强化疗药物的疗效，调节免疫细胞的新陈代谢，从而有可能重塑肿瘤微环境。虽然 SCFAs 和产生 SCFA 的微生物能提高多种癌症疗法的疗效，但已发表的数据也支持 SCFAs 会降低某些癌症疗法疗效的相反观点。因此，SCFA 与癌症之间的关系更为复杂，本综述将讨论其中的一些方面。显然，要了解 SCFAs 在癌症预防和治疗中的作用、机制和应用，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The role of short-chain fatty acids in cancer prevention and cancer treatment

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The role of short-chain fatty acids in cancer prevention and cancer treatment

Short-chain fatty acids (SCFAs) are microbial metabolites in the gut that may play a role in cancer prevention and treatment. They affect the metabolism of both normal and cancer cells, regulating various cellular energetic processes. SCFAs also inhibit histone deacetylases, which are targets for cancer therapy. The three main SCFAs are acetate, propionate, and butyrate, which are transported into cells through specific transporters. SCFAs may enhance the efficacy of chemotherapeutic agents and modulate immune cell metabolism, potentially reprogramming the tumor microenvironment. Although SCFAs and SCFA-generating microbes enhance therapeutic efficacy of several forms of cancer therapy, published data also support the opposing viewpoint that SCFAs mitigate the efficacy of some cancer therapies. Therefore, the relationship between SCFAs and cancer is more complex, and this review discusses some of these aspects. Clearly, further research is needed to understand the role of SCFAs, their mechanisms, and applications in cancer prevention and treatment.

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来源期刊

Archives of biochemistry and biophysics 生物-生化与分子生物学

CiteScore

7.40

自引率

0.00%

发文量

245

审稿时长

26 days

期刊介绍： Archives of Biochemistry and Biophysics publishes quality original articles and reviews in the developing areas of biochemistry and biophysics. Research Areas Include: • Enzyme and protein structure, function, regulation. Folding, turnover, and post-translational processing • Biological oxidations, free radical reactions, redox signaling, oxygenases, P450 reactions • Signal transduction, receptors, membrane transport, intracellular signals. Cellular and integrated metabolism.